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Table 2 Univariate Cox regression analysis

From: Prognostic significance of circulating microRNA-214 and -126 in dogs with appendicular osteosarcoma receiving amputation and chemotherapy

  Long-term DFS 1-year DFS Long-term OS 1-year OS
P-value HR 95%CI P-value HR 95%CI P-value HR 95%CI P-value HR 95%CI
Age (year) 8< 0.48 1.21 0.70–2.11 0.47 1.25 0.68–2.33 0.28 1.36 0.78–2.35 0.12 1.67 0.87–3.26
< 8 0.48 0.82 0.47–1.42 0.47 0.8 0.43–1.48 0.28 0.74 0.43–1.28 0.12 0.6 0.31–1.14
Weight (kg) 36< 0.23 1.41 0.80–2.46 0.34 1.37 0.72–2.57 0.37 1.29 0.73–2.26 0.62 1.18 0.60–2.30
< 36 0.23 0.71 0.41–1.25 0.34 0.73 0.39–1.39 0.37 0.78 0.44–1.37 0.62 0.85 0.43–1.66
Sex F and SF 0.49 1.21 0.70–2.11 0.58 0.84 0.45–1.57 0.71 0.9 0.52–1.57 0.76 0.9 0.47–1.75
M and CM 0.49 0.82 0.47–1.43 0.58 1.19 0.64–2.20 0.71 1.11 0.64–1.92 0.76 1.11 0.57–2.11
Primary site Femur 0.81 0.91 0.37–1.90 0.41 0.69 0.24–1.60 0.83 0.91 0.35–1.99 0.27 0.54 0.13–1.52
Humerus 0.3 1.36 0.76–2.38 0.13 1.65 0.86–3.07 0.38 1.29 0.72–2.25 0.32 1.41 0.71–2.71
Radius 0.45 0.81 0.45–1.40 0.56 0.83 0.43–1.55 0.5 0.82 0.46–1.44 0.98 1 0.51–1.93
Tibia 0.92 1.04 0.43–2.16 0.87 0.93 0.32–2.16 0.96 1.02 0.44–2.05 0.8 0.89 0.30–2.08
Ulna
Serum ALP (U/L) High (96<) 0.024 * 1.97 1.10–3.50 0.028 * 2.03 1.08–3.82 0.0021 ** 2.54 1.41–4.56 0.0015 ** 2.91 1.51–5.73
Low (< 96) 0.024 * 0.51 0.29–0.91 0.028 * 0.49 0.26–0.92 0.0021 ** 0.39 0.22–0.71 0.0015 ** 0.34 0.17–0.66
Monocyte (103 cells/μL) High (0.3<) 0.66 1.13 0.65–1.98 1 1 0.54–1.85 0.39 1.27 0.73–2.22 0.38 1.33 0.70–2.58
Low (< 0.3) 0.66 0.88 0.51–1.54 1 1 0.54–1.86 0.39 0.79 0.45–1.36 0.38 0.75 0.39–1.43
miR-214 (log2 ACRQ) High (−0.92<) 0.0004 *** 3.51 1.68–8.55 0.0007 *** 4.42 1.77–14.8 0.0012 ** 3.2 1.53–7.81 0.0054 ** 3.53 1.40–11.84
Low (<−0.92) 0.0004 *** 0.29 0.12–0.60 0.0007 *** 0.23 0.067–0.57 0.0012 ** 0.31 0.13–0.65 0.0054 ** 0.28 0.084–0.71
miR-126 (log2 ACRQ) High (1.4<) 0.002 ** 0.17 0.0066–0.54 0.0059 ** 0.14 0.0077–0.64
Low (< 1.4) 0.002 ** 8.6 1.87–152.48 0.0059 ** 7.28 1.57–129.33
  1. Circulating miR-214, miR-126, and serum ALP showed significant association with short disease-free survival (DFS) and overall survival (OS) in either or both the long-term and 1-year analysis, while the other parameters showed no significant association with the survivals. The statistical analysis for “ulna” in the primary site section was not performed due to the insufficient case number for statistical analysis. The best cut-off values were determined by using X-tile analysis. If the X-tile analysis failed to identify significant cut-off values (P-values less than 0.1), the median was employed as the cut-off value. HR, hazard ratio; 95% CI, 95% confidential interval. *P < 0.05, **P < 0.01, ***P < 0.001