Long-term DFS | 1-year DFS | Long-term OS | 1-year OS | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P-value | HR | 95%CI | P-value | HR | 95%CI | P-value | HR | 95%CI | P-value | HR | 95%CI | ||
Age (year) | 8< | 0.48 | 1.21 | 0.70–2.11 | 0.47 | 1.25 | 0.68–2.33 | 0.28 | 1.36 | 0.78–2.35 | 0.12 | 1.67 | 0.87–3.26 |
< 8 | 0.48 | 0.82 | 0.47–1.42 | 0.47 | 0.8 | 0.43–1.48 | 0.28 | 0.74 | 0.43–1.28 | 0.12 | 0.6 | 0.31–1.14 | |
Weight (kg) | 36< | 0.23 | 1.41 | 0.80–2.46 | 0.34 | 1.37 | 0.72–2.57 | 0.37 | 1.29 | 0.73–2.26 | 0.62 | 1.18 | 0.60–2.30 |
< 36 | 0.23 | 0.71 | 0.41–1.25 | 0.34 | 0.73 | 0.39–1.39 | 0.37 | 0.78 | 0.44–1.37 | 0.62 | 0.85 | 0.43–1.66 | |
Sex | F and SF | 0.49 | 1.21 | 0.70–2.11 | 0.58 | 0.84 | 0.45–1.57 | 0.71 | 0.9 | 0.52–1.57 | 0.76 | 0.9 | 0.47–1.75 |
M and CM | 0.49 | 0.82 | 0.47–1.43 | 0.58 | 1.19 | 0.64–2.20 | 0.71 | 1.11 | 0.64–1.92 | 0.76 | 1.11 | 0.57–2.11 | |
Primary site | Femur | 0.81 | 0.91 | 0.37–1.90 | 0.41 | 0.69 | 0.24–1.60 | 0.83 | 0.91 | 0.35–1.99 | 0.27 | 0.54 | 0.13–1.52 |
Humerus | 0.3 | 1.36 | 0.76–2.38 | 0.13 | 1.65 | 0.86–3.07 | 0.38 | 1.29 | 0.72–2.25 | 0.32 | 1.41 | 0.71–2.71 | |
Radius | 0.45 | 0.81 | 0.45–1.40 | 0.56 | 0.83 | 0.43–1.55 | 0.5 | 0.82 | 0.46–1.44 | 0.98 | 1 | 0.51–1.93 | |
Tibia | 0.92 | 1.04 | 0.43–2.16 | 0.87 | 0.93 | 0.32–2.16 | 0.96 | 1.02 | 0.44–2.05 | 0.8 | 0.89 | 0.30–2.08 | |
Ulna | – | – | – | – | – | – | – | – | – | – | – | – | |
Serum ALP (U/L) | High (96<) | 0.024 * | 1.97 | 1.10–3.50 | 0.028 * | 2.03 | 1.08–3.82 | 0.0021 ** | 2.54 | 1.41–4.56 | 0.0015 ** | 2.91 | 1.51–5.73 |
Low (< 96) | 0.024 * | 0.51 | 0.29–0.91 | 0.028 * | 0.49 | 0.26–0.92 | 0.0021 ** | 0.39 | 0.22–0.71 | 0.0015 ** | 0.34 | 0.17–0.66 | |
Monocyte (103 cells/μL) | High (0.3<) | 0.66 | 1.13 | 0.65–1.98 | 1 | 1 | 0.54–1.85 | 0.39 | 1.27 | 0.73–2.22 | 0.38 | 1.33 | 0.70–2.58 |
Low (< 0.3) | 0.66 | 0.88 | 0.51–1.54 | 1 | 1 | 0.54–1.86 | 0.39 | 0.79 | 0.45–1.36 | 0.38 | 0.75 | 0.39–1.43 | |
miR-214 (log2 ACRQ) | High (−0.92<) | 0.0004 *** | 3.51 | 1.68–8.55 | 0.0007 *** | 4.42 | 1.77–14.8 | 0.0012 ** | 3.2 | 1.53–7.81 | 0.0054 ** | 3.53 | 1.40–11.84 |
Low (<−0.92) | 0.0004 *** | 0.29 | 0.12–0.60 | 0.0007 *** | 0.23 | 0.067–0.57 | 0.0012 ** | 0.31 | 0.13–0.65 | 0.0054 ** | 0.28 | 0.084–0.71 | |
miR-126 (log2 ACRQ) | High (1.4<) | – | – | – | 0.002 ** | 0.17 | 0.0066–0.54 | – | – | – | 0.0059 ** | 0.14 | 0.0077–0.64 |
Low (< 1.4) | – | – | – | 0.002 ** | 8.6 | 1.87–152.48 | – | – | – | 0.0059 ** | 7.28 | 1.57–129.33 |