Fig. 3

Disease-free survival prediction using the integrated grading system. The integrated grading system using miR-214, − 126, and serum ALP showed more accurate disease-free survival (DFS) prediction than the single ALP grading system. Grading criteria, Kaplan-Meier (KM) survival curves, median survival time (MST), statistical significance, survival rates, and case distribution of the integrated and single ALP grades in the prediction of (a) long-term and (b) 1-year DFS. Grade 1, 2, and 3 were indicated as G1, G2, and G3 in this figure, respectively. P-values were calculated by using the log-rank test or the log-rank test for trend. A P-value less than 0.05 was considered as significant (*P < 0.05, **P < 0.01, ***P < 0.001)