Fig. 2

Univariate prognostic potential of circulating miR-214, − 126, and other variables. Circulating miR-214, − 126, and serum ALP showed significant association with short disease-free survival (DFS) and overall survival (OS), although circulating miR-126 was prognostic only in the 1-year analysis. Circulating miR-214 discriminated the long-term survivors well while serum ALP did not. (a) X-tile analysis for determining the best cut-off values of the variables. The arrowheads indicate the best cut-off point for each variable. The red and green in the heatmap indicate high chi-square values toward good and poor prognosis, respectively. Kaplan-Meier curves indicating (b) DFS and (c) OS with the separation by the best-cut off for miR-214, miR-126, and serum ALP in long-term and 1-year analysis. P-values were calculated by using the log-rank test. P-values less than 0.05 were considered to be significant