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Table 5 Detail of adverse effects of systemic and topical therapies with score 2, 1 and 0. Reference 9 is repeated twice because two different protocols were tested in the same study

From: Critically appraised topic for the most effective and safe treatment for canine generalised demodicosis

Reference Therapy Adverse effects score Type of adverse event N. of cases
[6] IVERMECTIN 2 Mild toxicosis 1
[8] MILBEMICINE OXIME 1 Diarrhoea and neurological signs 7
[9] IVERMECTIN tablets 1 • Ataxia 3
• Lethargia 3
• Sialorrhea 2
• Disorexia 1
• Apathy 1
• Aggressive behavior 1
[9] MOXIDECTIN 1 • Emesis 8
   • Disorexia 2
• Anorexia 2
• Sialorrhea 2
• Adipsia 1
• Diarrhea 1
• Lethargia 4
• Apatia 2
• Myoclonia 1
• Enanthema 1
[11] IMIDACLOPRID+MOXIDECTIN 2 • Transient erythema 1
• Scaling 1
[12] DORAMECTIN 2 Mild ataxia 1
[13] MOXIDECTIN 1 • Ataxia 2
• Lethargia, vomiting 1
[17] IVERMECTIN 1 • Transient neurotoxicosis with bilateral mydriasis, decreased to absent pupillary light response, ataxia and generalized muscle weakness, vomiting, coma (1 dog) 4