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Table 5 Detail of adverse effects of systemic and topical therapies with score 2, 1 and 0. Reference 9 is repeated twice because two different protocols were tested in the same study

From: Critically appraised topic for the most effective and safe treatment for canine generalised demodicosis

Reference

Therapy

Adverse effects score

Type of adverse event

N. of cases

[6]

IVERMECTIN

2

Mild toxicosis

1

[8]

MILBEMICINE OXIME

1

Diarrhoea and neurological signs

7

[9]

IVERMECTIN tablets

1

• Ataxia

3

• Lethargia

3

• Sialorrhea

2

• Disorexia

1

• Apathy

1

• Aggressive behavior

1

[9]

MOXIDECTIN

1

• Emesis

8

  

• Disorexia

2

• Anorexia

2

• Sialorrhea

2

• Adipsia

1

• Diarrhea

1

• Lethargia

4

• Apatia

2

• Myoclonia

1

• Enanthema

1

[11]

IMIDACLOPRID+MOXIDECTIN

2

• Transient erythema

1

• Scaling

1

[12]

DORAMECTIN

2

Mild ataxia

1

[13]

MOXIDECTIN

1

• Ataxia

2

• Lethargia, vomiting

1

[17]

IVERMECTIN

1

• Transient neurotoxicosis with bilateral mydriasis, decreased to absent pupillary light response, ataxia and generalized muscle weakness, vomiting, coma (1 dog)

4