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Table 4 Efficacy of topical therapies against generalised demodicosis in dogs. Reference 14 is repeated twice because two different protocols were tested in the same study

From: Critically appraised topic for the most effective and safe treatment for canine generalised demodicosis

Reference Therapy Posology Adverse effects Treatment duration Efficacy
[4] AMITRAZ From 3 to 6 applications at 14-days intervals. 3 2 3
[8] IMIDACLOPRID+MOXIDECTIN From 2 to 4 applications at 28-days intervals. 3 2 3
[11] IMIDACLOPRID+MOXIDECTIN Group 1 treated at 28-days intervals max 4 times; group 2 at 7-days intervals max 16 times. 2 1 3 (Group 1) 3 (Group 2)
[14] FIPRONIL + METHOPRENE + AMITRAZ Group 1 treated at 28-days intervals; group 2 treated at 14-days intervals. 3 2 3 (Group 1) 3 (Group 2)
[14] METAFLUMIZONE + AMITRAZ Group 3 treated at 28-days intervals. 3 2 3
[16] IMIDACLOPRID+MOXIDECTIN ADV1 treated monthly; ADV2 biweekly; ADV4 weekly. 3 2 1 (ADV1) 2 (ADV2) AND 3 (ADV4)
[17] IMIDACLOPRID+MOXIDECTIN ADV1 treated monthly; ADV2 biweekly; ADV4 weekly. 3 1 1 (ADV1) 2 (ADV2) AND 3 (ADV3)
[18] IMIDACLOPRID+MOXIDECTIN 3 applications at 28-days intervals. 3 2 3
[19] IMIDACLOPRID+MOXIDECTIN Weekly from day 0 to day 81. 3 2 3
[20] IMIDACLOPRID+MOXIDECTIN 4 applications at 14-days intervals. 3 2 3
[23] IMIDACLOPRID+MOXIDECTIN From 2 to 6 applications at 7 or 28-days intervals 3 2 3