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Table 3 Efficacy of systemic therapies against generalised demodicosis in dogs. References 9 and 22 are repeated twice because two different protocols were tested in the same study

From: Critically appraised topic for the most effective and safe treatment for canine generalised demodicosis

Reference Therapy Posology Adverse effects Treatment duration Efficacy
[5] MILBEMYCIN OXIME 1–2 mg/kg per os every 24 h. not reported 2 3
[6] IVERMECTIN 0.6 mg/kg per os every 24 h. 2 2 3
[7] MILBEMYCINE OXIME 0.5–1.6 mg/kg per os every 24 h. 3 2 3
[8] MILBEMYCIN OXIME 0.5–1 mg/kg or 1–2 mg/kg every 24 h. for 4 weeks. 1 2 3
[9] IVERMECTIN tablets 0.6 mg/kg per os every 24 h. 1 1 3
[9] MOXIDECTIN 0.5 mg/kg per os every 72 h. 1 1 3
[12] DORAMECTIN 0.6 mg/kg per os weekly. 2 2 2
[13] MOXIDECTIN 0.4 mg/kg per os every 24 h. 1 2 3
[16] IVERMECTIN 0.5 mg/kg per os every 24 h. 3 2 3
[17] IVERMECTIN 0.5 mg/kg per os every 24 h. 1 1 3
[18] FLURALANER 25 mg/kg per os once. 3 2 3
[19] SAROLANER 2 mg/kg per os every 30 days for 3 times. 3 2 3
[20] AFOXOLANER 2.5 mg/kg per os every 2 weeks for 4 times. 3 2 3
[21] LOTILANER 20 mg/kg per os monthly for 3 times. 3 2 3
[22] DORAMECTIN 600 μg/kg s.c. once a week 3 2 3
[22] DORAMECTIN 600 μg/kg per os twice a week 3 2 3
[23] SAROLANER 2–4 mg/kg per os every 30 days 3 2 3
[24] FLURALANER 25–50 mg/kg per os once or every 12 weeks 3 2 3