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Table 1 Clinical signs of conventional weaned pigs after PEDV inoculation at 40 days of age and challenge at 24 dpi

From: Pathogenicity and immunogenicity of attenuated porcine epidemic diarrhea virus PC22A strain in conventional weaned pigs

  After inoculation, pre-P3-challenge (1 to 21 dpi) After P3 challenge (25 to 33 dpi/1 to 9 dpc)
P3 (n = 6) P100C4 (n = 6) P120 (n = 6) Mock (n = 6) P3 (n = 4) P100C4 (n = 4) P120 (n = 4) Mock (n = 4)
PEDV diarrhea rate (%) 100 0 0 0 0 100 100 100
Mortality (%) 0 0 0 0 0 0 0 0
Duration of diarrhea (days, FC ≥ 2) 2.66 ± 1.37 a 0.00 ± 0.00 b 0.00 ± 0.00 b 0.00 ± 0.00 b 0.00 ± 0.00 c 3.25 ± 0.50 b 4.50 ± 0.58 a 4.00 ± 0.82 a, b
Cumulative FC scores 8.00 ± 1.79 a 0.33 ± 0.52 b 1.33 ± 2.00 b 1.67 ± 0.98 b 0.50 ± 1.00 c 9.25 ± 0.50 b 13.50 ± 1.73 a 12.00 ± 0.82 a
Highest viral shedding titer log10 N gene copies/ml) 11.63 ± 0.41 9.88 ± 2.71 * 10.97 ± 1.61 NA 5.65 ± 1.59 11.75 ± 0.38 12.02 ± 0.64 12.28 ± 0.33
Duration of fecal PEDV RNA shedding (days) 12.83 ± 2.56 a 2.00 ± 1.00 b 1.17 ± 0.41 b NA 2.00 ± 1.92 c 7.50 ± 1.00 b >  9 a >  9 a
Weekly body weight gain (kg) ** −0.3 ± 2.67 b 1.83 ± 1.76 a 2.28 ± 0.61 a 1.90 ± 0.77 a 2.79 ± 0.29 a 3.98 ± 2.32 a 3.55 ± 0.62 a − 0.45 ± 2.53 b
  1. *One pig in P100C4 group did not shed PEDV RNA in feces; ** during the 1st week post-inoculation or challenge
  2. a, b, cDifferent letters in each column denote differences among groups (P < 0.05)
  3. dpi: days post-inoculation, dpc: days post-challenge, FC: fecal consistency (0, solid; 1, pasty; 2, semi-liquid; 3, liquid), N: nucleocapsid, NA: not available