Table 1 Clinical signs of conventional weaned pigs after PEDV inoculation at 40 days of age and challenge at 24 dpi

PEDV diarrhea rate (%)

100

0

0

0

0

100

100

100

Mortality (%)

0

0

0

0

0

0

0

0

Duration of diarrhea (days, FC ≥ 2)

2.66 ± 1.37 ^a

0.00 ± 0.00 ^b

0.00 ± 0.00 ^b

0.00 ± 0.00 ^b

0.00 ± 0.00 ^c

3.25 ± 0.50 ^b

4.50 ± 0.58 ^a

4.00 ± 0.82 ^{a, b}

Cumulative FC scores

8.00 ± 1.79 ^a

0.33 ± 0.52 ^b

1.33 ± 2.00 ^b

1.67 ± 0.98 ^b

0.50 ± 1.00 ^c

9.25 ± 0.50 ^b

13.50 ± 1.73 ^a

12.00 ± 0.82 ^a

Highest viral shedding titer log₁₀ N gene copies/ml)

11.63 ± 0.41

9.88 ± 2.71 ^*

10.97 ± 1.61

NA

5.65 ± 1.59

11.75 ± 0.38

12.02 ± 0.64

12.28 ± 0.33

Duration of fecal PEDV RNA shedding (days)

12.83 ± 2.56 ^a

2.00 ± 1.00 ^b

1.17 ± 0.41 ^b

NA

2.00 ± 1.92 ^c

7.50 ± 1.00 ^b

>  9 ^a

>  9 ^a

Weekly body weight gain (kg) ^**

−0.3 ± 2.67 ^b

1.83 ± 1.76 ^a

2.28 ± 0.61 ^a

1.90 ± 0.77 ^a

2.79 ± 0.29 ^a

3.98 ± 2.32 ^a

3.55 ± 0.62 ^a

− 0.45 ± 2.53 ^b