Fig. 2

Pedigree of a Komondor dog kindred with hereditary selective intestinal cobalamin malabsorption. Squares and circles are males and females, respectively. Filled symbols indicate affected dogs. Offspring in a single litter are arranged on a horizontal line that connects lines descending from the parents’ symbols. The arrow points to the index case (case 5, Additional file 1), and the checkered symbol indicates case 4 that died without biochemical or molecular diagnosis. Half-filled symbols indicate carriers of the disease allele determine by genotyping the CUBN c.NM_001003148.1; c.8746 + 1G > A variant. Genotypes of dogs determined as in Fig. 3b are indicated below or immediately adjacent to their symbols. Open symbols indicate dogs which were not genotyped