Fig. 3

Values of prepill 1 and prepill 2 cortisol concentrations in three dogs (a-c). Dog A: stayed in the hospital at 1st re-evaluation (RE), barking the whole time. At the 2nd and 3rd RE the dog went home with owner. Constant trilostane dose of 1 mg/kg BID for all REs. Dog B: Difficulties at 1st RE in drawing blood for prepill 1; no problems drawing blood for prepill 2. No problems drawing blood at 2nd RE. Constant trilostane dose of 1 mg/kg BID for both REs. Dog C: Dog always very excited upon arrival. Stays in the hospital at each RE and calms down. Increasing trilostane doses between 1st and 4th RE (1.3–3.3 mg/kg BID). The grey area represents the defined cortisol target range