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Table 2 Original case series: Details of the high-dose pulse glucocorticoid therapy

From: Feline pemphigus foliaceus: original case series and a comprehensive literature review

High-Dose Glucocorticoid Pulse Therapy # cats % cats Time to Disease Control Cumulative Dose of Steroids Number of Pulses
Median Mean Range Median Mean Range Median Mean Range
Total # of cats receiving high dose GC pulse therapy 12         1 2 (1–3)
Cats achieving DC within 4 weeks of the high dose GC pulse therapy 7 58% 14 14 (7–28) 165 198 (115–324) 1 1 1
Cats failing to reach DC within 4 weeks of the high dose GC pulse therapy (eventually reaching DC with different TXa) 3 25% 80 131 (43–269) 465 543 (465–710) 2 2 2
Cats treated with high dose GC pulse therapy that failed to reach DC (including other treatment strategies) 2 17%        3 3 3
  1. Cumulative dose of glucocorticoids up to the time of disease control was calculated as a prednisolone equivalent for 5 kg cat. Following estimated steroid equivalency conversions were used: dexamethasone and triamcinolone acetonide about seven times and methylprednisolone 1.3 times more potent than prednisolone [41, 42]. Due to the low bioavailability of prednisone in cats [94,95,96], the equivalency conversion between prednisone and prednisolone could not be determined and, therefore, the single case in which prednisone was used to induce disease control was excluded from the cumulative dose calculation
  2. aOne of these cats achieved disease control with high-dose pulse glucocorticoid therapy within 43 days (after the second pulse). The remaining cats achieved disease control with other treatment regimens