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Table 1 Original case series: Treatment details at the time of disease control

From: Feline pemphigus foliaceus: original case series and a comprehensive literature review

Treatment at the Time of Disease Control # cats % cats Time to Disease Control (days) Dosages of GC at the Time of Disease Control (mg/kg/day) Cumulative Dose of GC up to DC (mg) (prednisolone equivalent for 5 kg cat)
Median Mean Range Median Mean Range Median Mean Range
Standard GC Monotherapy 16 52% 14 21 (7–50)     280 306 (35–640)
prednisolone 13 42% 14 18 (8–31) 3 3 0.7–5.5 280 298 (35–600)
prednisone 1 3% 12 4.4 NA
triamcinolone 1 3% 42 0.3 640
dexamethasone 1 3% 50 0.1 72
Non-Steroidal Immunosuppressants as a Monotherapy or Combination Therapy 6 19% 58 105 (24–269)     433 412 (180–710)
GC + ciclosporin 2 6% 149 149 (28–269) 6 7 (5–10) 490 490 (270–710)
GC + ciclosporin + topical GC 2 6% 52 52 (24–80) 449 449 (433–465)
GC + chlorambucil 1 3% 36 0.2 [every other day] 0.2 [every other day] (0.15–0.3) [every other day] 180
chlorambucil + topical GC 1 3% 192    
Topical GC only 1 3% 28       
  1. Cumulative dose of glucocorticoids up to the time of disease control was calculated as a prednisolone equivalent for 5 kg cat. Following estimated steroid equivalency conversions were used: dexamethasone and triamcinolone acetonide about seven times and methylprednisolone 1.3 times more potent than prednisolone [41, 42]. Due to the low bioavailability of prednisone in cats [94,95,96], the equivalency conversion between prednisone and prednisolone could not be determined and, therefore, the single case in which prednisone was used to induce disease control was excluded from the cumulative dose calculation