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Table 2 Heat Stability Study of EAS at 4 °C, 25 °C and 37 °C (values are shown as means ±SD, n = 3)

From: Development of a novel oil-in-water emulsion and evaluation of its potential adjuvant function in a swine influenza vaccine in mice

EAS

Time (months)

T0

1

3

6

9

12

18

24

4 °C

Particle size

104 ± 2

104 ± 2

101 ± 3

105 ± 1

104 ± 2

105 ± 2

107 ± 2

106 ± 2

Zeta potential

−38.8 ± 0.1

−38.3 ± 0.4

− 38.5 ± 0.2

− 38.8 ± 0.2

− 38.7 ± 0.2

−38.5 ± 0.2

− 38.7 ± 0.02

−38.3 ± 0.3

pH

6.8 ± 0.1

6.7 ± 0.2

6.8 ± 0.1

6.6 ± 0.3

6.8 ± 0.1

6.8 ± 0.1

6.7 ± 0.3

6.7 ± 0.2

Viscosity

2.01 ± 0.14

2.01 ± 0.21

1.90 ± 0.17

1.94 ± 0.17

2.04 ± 0.15

2.11 ± 0.01

1.99 ± 0.04

2.03 ± 0.12

25 °C

Particle size

104 ± 2

103 ± 3

109 ± 1

114 ± 2

141 ± 9

ND

ND

ND

Zeta potential

−38.3 ± 0.1

−38.4 ± 0.5

−38.7 ± 0.3

−38.5 ± 0.5

−35.4 ± 0.4

ND

ND

ND

pH

6.8 ± 0.2

6.5 ± 0.3

6.8 ± 0.1

6.5 ± 0.3

6.6 ± 0.2

ND

ND

ND

Viscosity

2.01 ± 0.05

2.04 ± 0.01

2.24 ± 0.23

2.17 ± 0.05

2.43 ± 0.22

ND

ND

ND

37 °C

Particle size

105 ± 2

107 ± 2

115 ± 2

157 ± 12

ND

ND

ND

ND

Zeta potential

−38.6 ± 0.3

−38.4 ± 0.2

−36.9 ± 0.3

−35.8 ± 0.4

ND

ND

ND

ND

pH

6.8 ± 0.2

6.5 ± 0.3

6.6 ± 0.2

6.7 ± 0.2

ND

ND

ND

ND

Viscosity

2.03 ± 0.11

2.11 ± 0.18

2.34 ± 0.19

2.55 ± 0.38

ND

ND

ND

ND