Table 5 In vivo PK/PD parameters of enrofloxacin in E. coli O78-infected chicks using the combined concentration of enrofloxacin and ciprofloxacin for simulation

E_max (Log ₁₀ cfu/mL)

−5.8

−4.7

−4.4

EC₅₀

18.28

17.66

13.59

E₀ (Log ₁₀ cfu/mL)

1.78

1.68

2.29

AUC_0–24/MIC for 1 log₁₀ cfu/mL killing

9.74

14.01

9.49

AUC_0–24/MIC for 3 log₁₀ cfu/mL killing

21.29

41.68

27.65

AUC_0–24/MIC for 4 log₁₀ cfu/mL killing

32.13

60.52

57.24

Slope (N)

4.19

2.67

4.86