Table 4 In vivo PK/PD parameters of enrofloxacin in E. coli O78-infected chicks using the concentration of enrofloxacin for simulation

E_max (Log ₁₀ cfu/mL)

−5.8

− 4.7

−4.4

EC₅₀

16.61

16.93

10.33

E₀ (Log ₁₀ cfu/mL)

1.78

1.68

2.29

AUC_0–24/MIC for 1 log₁₀ cfu/mL killing

9.29

12.42

9.1

AUC_0–24/MIC for 3 log₁₀ cfu/mL killing

19.32

32.15

23.41

AUC_0–24/MIC for 4 log₁₀ cfu/mL killing

28.17

52.52

56.36

Slope (N)

2.58

2.36

3.01