Table 3 Pharmacokinetic parameters of ciprofloxacin in serum after oral administration of 1, 10, and 20 mg/kg body weight enrofloxacin in E. coli O78-infected chicks (mean and SD, n = 10)
Parameters | 1 mg/kg | 10 mg/kg | 20 mg/kg |
|---|---|---|---|
Cmax (μg/mL) | 0.03 ± 0.001 | 0.10 ± 0.03 | 0.37 ± 0.05 |
Tmax (h) | 5 ± 1.05 | 4.3 ± 1.98 | 4.4 ± 1.58 |
T1/2β (h) | 27.25 ± 7.76 | 19.51 ± 2.60 | 18.77 ± 4.11 |
AUC0–24 (h·μg/mL) | 0.61 ± 0.03 | 1.42 ± 0.15 | 4.93 ± 0.76 |
CL/F (mL/h/kg) | 0.67 ± 0.11 | 3.96 ± 0.78 | 2.26 ± 0.46 |