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Fig. 3 | BMC Veterinary Research

Fig. 3

From: Overcoming species barriers: an outbreak of Lagovirus europaeus GI.2/RHDV2 in an isolated population of mountain hares (Lepus timidus)

Fig. 3

Microscopic lesions and viral antigen localization in mountain hares (Lepus timidus) that died of Lagovirus europaeus GI.2/RHDV2/b infection. a Acute hepatocellular apoptosis and necrosis. Dead cells are denoted with an arrow and they frequently are surrounded by heterophils. The portal region is denoted by an asterisk. b Acute hepatocellular apoptosis and necrosis (arrows). Arrowhead denote hepatocellular calcification and the asterisk marks the portal area. Insert: von Kossa histochemical stain with calcium granules stained black. c Immunohistochemical visualization of viral capsid antigen (brown) in the liver of hare 2147. Arrows denote hepatocytes with both intracytoplasmic and intranuclear staining. d Immunohistochemical visualization of viral capsid antigen (brown) in the liver of hare 1208. Intracytoplasmic staining of hepatocytes (arrow) and Kupffer cells (arrowhead). e Immunohistochemical visualization of viral capsid antigen (brown) in the spleen of hare 1208. Arrows indicate intracytoplasmic staining of macrophages in the red pulp. f Negative immunoglobulin control of the liver of 1208

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