From: Expanding behavior pattern sensitivity analysis with model selection and survival analysis
Parameter | Distribution | Definition |
---|---|---|
CTC pharmacokinetics | ||
δ | Beta (0.54, 37.4) | CTC abiotic degradation rate |
γs | Uniform (0.0535, 0.0895) | CTC flow rate from stomachs to small intestine |
γupper_si | Uniform (0.250, 0.416) | CTC flow rate through the upper 1/3 small intestine |
γrest_si | Uniform (0.100, 0.166) | CTC flow rate through the lower 2/3 small intestine |
γLI | Uniform (0.100, 0.166) | CTC flow rate through large intestine |
Eb | Uniform (0.39, 0.64) | Fraction CTC eliminated via bile |
ηLI | Uniform (0.69, 0.89) | Fraction CTC adsorbed to digesta in the large intestine |
VLI | Uniform (6, 22) | Large intestine contents volume |
CTC pharmacodynamics | ||
Hs | Uniform (1.62, 2.23) | Hill coefficient for susceptible bacteria |
Hi | Uniform (5.71, 9.53) | Hill coefficient for intermediate bacteria |
Hr | Uniform (6.42, 10) | Hill coefficient for resistant bacteria |
MICs | Uniform (0, 4) | Anaerobic MIC for susceptible bacteria |
MICi | Uniform (2.7, 16) | Anaerobic MIC for intermediate bacteria |
MICr | Uniform (14.7, 128) | Anaerobic MIC for resistant bacteria |
Bacterial population dynamics in the large intestine | ||
r | Uniform (0.05, 0.5) | Bacterial growth rate in the large intestine |
α | Uniform (0, 0.03) | Fitness cost for intermediate and resistant bacteria |
log10(Nmax) | Weibull (14.03, 20.32) − 7.59 | Large intestine carrying capacity for the bacteria |
Nstart | Uniform (0.1, 0.9) * Nmax | Starting bacterial population size |
log10(βjk) | Gamma (94.17,0.16) − 22.57 | transposon transfer rate between /transposon transfer rate between E. coli subpopulations |
λin | Uniform (0.001, 0.01) | Bacterial in-flow rate to the large intestine |
λout | Uniform (0.01, 0.02) | Bacterial out-flow rate from the large intestine |
pi | Uniform (0.02, 0.15) | Proportion intermediate in in-flowing bacteria |
pr | Uniform (0.16, 0.61) | Proportion resistant in in-flowing bacteria |
ps | 1- pi - pr | Proportion susceptible in in-flowing bacteria |
startj | Same as pj | Starting proportions of resistant (startr), intermediate (starti), and susceptible (starts) bacteria in the large intestine |