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Fig. 6 | BMC Veterinary Research

Fig. 6

From: Expanding behavior pattern sensitivity analysis with model selection and survival analysis

Fig. 6

Schematic of the example mathematical model of tetracycline-resistant Escherichia coli in beef cattle administered oral chlortetracycline. Pharmacokinetic parameters related to the distribution of chlortetracycline throughout the gastrointestinal tract and excretion via urine and bile are presented in red. The black parameters are pharmacokinetic constants and were not varied during simulations: absorption rates from the small intestine (ka), excretion rates (ke) and distribution to (kpt) and from (ktp) tissues. Pharmacodynamic parameters related to the effect of the large intestine chlortetracycline concentration on enteric E. coli are given in blue. Parameters related to the bacterial population dynamics are given in green. The definition and distribution of each parameter are presented in Table 6

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