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Table 1 Clinical and histopathological characteristics of appendicular OSA cases included in metastasis and survival analyses

From: An evaluation of TAZ and YAP crosstalk with TGFβ signalling in canine osteosarcoma suggests involvement of hippo signalling in disease progression

Case

BREED

SEX

Age Dx (Y)

Weight Dx (kg)

Location

ALP Status

Survival Days

Metastasis

pSmad2 Levels

TAZ

Levels

YAP

Levels

Grade

Kirp

Louko

1

Standard Poodle

CM

10.55

23.6

right proximal tibia

N

91

84

High

High

N/A

3

3

2

Doberman

SF

5.99

32.4

right distal femur

H

116

93

High

High

Low

2

3

3

Rottweiler

M

6.30

53.0

left proximal humerus

H

130

N/A

High

Low

Low

2

1

4

Australian Shepherd

CM

8.32

24.6

right proximal humerus

N

148

78

High

High

High

2

2

5

Rottweiler

CM

8.26

50.0

right distal radius

H

165

131

High

Low

High

2

2

6

Greyhound

SF

8.87

26.0

right distal femur

N

215

N/A

High

Low

High

3

2

7

Mixed breed

CM

8.30

37.4

left distal radius

N

218

167

Low

High

High

2

1

8

Rottweiler

CM

4.66

53.4

left proximal humerus

N

282

182

Low

High

High

2

3

9

Golden Retriever

CM

10.99

32.2

left proximal tibia

N

294a

247

Low

Low

High

2

1

10

Mixed breed

CM

10.02

42.0

left distal tibia

N

301

N/A

High

High

High

2

1

11

Mixed breed

CM

7.25

51.0

left distal tibia

N

381

N/A

High

High

High

2

2

12

Doberman

SF

5.91

41.0

right distal radius

N

485a

485a

High

Low

High

3

3

13

Mixed breed

CM

8.03

28.4

left proximal femur

N

605

604

Low

Low

Low

2

1

14

Greyhound

CM

9.02

29.4

right distal femur

N

1005

1005a

High

High

N/A

2

1

15

Mixed breed

CM

8.25

37.2

left proximal femur

N

1386

1386a

Low

High

Low

2

1

16

Greyhound

SF

7.43

32.4

left distal tibia

H

1091a

1091a

Low

Low

Low

2

1

  1. MC male castrated, FS female spayed, ALP alkaline phosphatase status, H high, N normal, L low; Kirp, Grade assigned using criteria as explained in Kirpensteijn et al. [28]; Louko, Grade assigned using criteria as explained in Loukopoulos et al. [29];
  2. N/A Data not available
  3. aData was censored for Kaplan-Meier analysis