Table 4 Ex vivo AUC24h/MIC value (mean ± SD, n = 8) of tylosin after IM administration at a dose rate of 10 mg/kg
From: Pharmacokinetic-pharmacodynamic modeling of tylosin against Streptococcus suis in pigs
Time(h) | Healthy Pigs | Infected Pigs | ||
|---|---|---|---|---|
AUC24 h/MIC(h) (Mean ± SD) | E | AUC24 h/MIC(h) (Mean ± SD) | E | |
0 | 0 | 3.23 | 0 | 3.345 |
0.17 | 10.587 ± 3.835 | −1.199 | 11.832 ± 4.979 | −1.833 |
0.33 | 16.617 ± 4.260 | −1.895 | 22.185 ± 8.413 | −2.633 |
0.5 | 24.177 ± 5.010 | −2.614 | 30.768 ± 11.325 | −2.879 |
1 | 35.904 ± 7.518 | −2.932 | 49.743 ± 13.588 | −3.234 |
1.5 | 46.572 ± 11.173 | −3.085 | 62.532 ± 14.423 | −3.620 |
2 | 56.271 ± 13.789 | −3.488 | 56.343 ± 14.827 | −3.431 |
3 | 49.797 ± 13.062 | −3.329 | 40.374 ± 14.276 | −3.091 |
4 | 32.676 ± 10.897 | −2.800 | 26.565 ± 13.558 | −2.716 |
6 | 13.854 ± 5.403 | −1.462 | 12.162 ± 8.473 | −1.338 |
8 | 4.794 ± 2.640 | 0.587 | 6.189 ± 5.428 | −0.212 |
10 | 2.712 ± 1.409 | 1.093 | 3.393 ± 2.693 | 0.319 |
12 | 1.452 ± 0.750 | 1.184 | 1.578 ± 0.979 | 0.382 |