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Table 4 Ex vivo AUC24h/MIC value (mean ± SD, n = 8) of tylosin after IM administration at a dose rate of 10 mg/kg

From: Pharmacokinetic-pharmacodynamic modeling of tylosin against Streptococcus suis in pigs

Time(h) Healthy Pigs Infected Pigs
AUC24 h/MIC(h) (Mean ± SD) E AUC24 h/MIC(h) (Mean ± SD) E
0 0 3.23 0 3.345
0.17 10.587 ± 3.835 −1.199 11.832 ± 4.979 −1.833
0.33 16.617 ± 4.260 −1.895 22.185 ± 8.413 −2.633
0.5 24.177 ± 5.010 −2.614 30.768 ± 11.325 −2.879
1 35.904 ± 7.518 −2.932 49.743 ± 13.588 −3.234
1.5 46.572 ± 11.173 −3.085 62.532 ± 14.423 −3.620
2 56.271 ± 13.789 −3.488 56.343 ± 14.827 −3.431
3 49.797 ± 13.062 −3.329 40.374 ± 14.276 −3.091
4 32.676 ± 10.897 −2.800 26.565 ± 13.558 −2.716
6 13.854 ± 5.403 −1.462 12.162 ± 8.473 −1.338
8 4.794 ± 2.640 0.587 6.189 ± 5.428 −0.212
10 2.712 ± 1.409 1.093 3.393 ± 2.693 0.319
12 1.452 ± 0.750 1.184 1.578 ± 0.979 0.382