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Table 2 Pharmacokinetic parameters of tylosin (n = 8) after 10 mg/kg IM administration in pigs

From: Pharmacokinetic-pharmacodynamic modeling of tylosin against Streptococcus suis in pigs

Parameter

Unit

Healthy (mean ± SD)

Porcine streptococcosis (mean ± SD)

ka

1/h

0.521 ± 0.061

0.759 ± 0.372*

ke

1/h

0.518 ± 0.060

0.634 ± 0.152*

AUC

h·μg/mL

10.804 ± 2.204

10.297 ± 3.458

T1/2ka

h

1.347 ± 0.155

1.060 ± 0.383*

T1/2ke

h

1.354 ± 0.150

1.152 ± 0.293

Tmax

h

1.948 ± 0.219

1.578 ± 0.487*

Cmax

μg/mL

2.056 ± 0.426

2.372 ± 0.376

AUMC

h·h·μg /mL

36.169 ± 6.570

35.531 ± 17.647

MRT

h

3.588 ± 0.469

3.353 ± 0.694

CL/F

mL/min

15.944 ± 2.946

18.1326 ± 7.265

  1. Pharmacokinetics parameters and variables were calculated using a one-compartment model with first order input and output: ka is absorption rate constant; ke is elimination rate constant; T1/2ka is absorption half-life; T1/2ke is elimination half-life; Cmax is maximum concentration in serum; Tmax is the time to achieve the maximum serum concentration; AUC is area under serum concentration-time curve; AUMC is area under the first moment curve; MRT is mean residence time; CL/F is the body clearance corrected for bioavailability
  2. *means significance difference (P < 0.05)
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BMC Veterinary Research

ISSN: 1746-6148

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