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Table 2 Pharmacokinetic parameters of tylosin (n = 8) after 10 mg/kg IM administration in pigs

From: Pharmacokinetic-pharmacodynamic modeling of tylosin against Streptococcus suis in pigs

Parameter Unit Healthy (mean ± SD) Porcine streptococcosis (mean ± SD)
ka 1/h 0.521 ± 0.061 0.759 ± 0.372*
ke 1/h 0.518 ± 0.060 0.634 ± 0.152*
AUC h·μg/mL 10.804 ± 2.204 10.297 ± 3.458
T1/2ka h 1.347 ± 0.155 1.060 ± 0.383*
T1/2ke h 1.354 ± 0.150 1.152 ± 0.293
Tmax h 1.948 ± 0.219 1.578 ± 0.487*
Cmax μg/mL 2.056 ± 0.426 2.372 ± 0.376
AUMC h·h·μg /mL 36.169 ± 6.570 35.531 ± 17.647
MRT h 3.588 ± 0.469 3.353 ± 0.694
CL/F mL/min 15.944 ± 2.946 18.1326 ± 7.265
  1. Pharmacokinetics parameters and variables were calculated using a one-compartment model with first order input and output: ka is absorption rate constant; ke is elimination rate constant; T1/2ka is absorption half-life; T1/2ke is elimination half-life; Cmax is maximum concentration in serum; Tmax is the time to achieve the maximum serum concentration; AUC is area under serum concentration-time curve; AUMC is area under the first moment curve; MRT is mean residence time; CL/F is the body clearance corrected for bioavailability
  2. *means significance difference (P < 0.05)