Table 1 Relationship between proliferation indices (mitotic count and Ki-67 index) and clinicopathologic variables in 50 cases of feline non-ocular melanocytic tumors
From: Evaluation of Ki-67 expression in feline non-ocular melanocytic tumours
Variables | Number of cases | Median mitotic count (range) | P | Median Ki-67 index (range) | P |
|---|---|---|---|---|---|
Tumor location | 0.396 | 0.984 | |||
skin | 33 | 15 (0–153) | 29% (1–78%) | ||
mucosae | 17 | 15 (2–48) | 22% (10–68%) | ||
Largest diametera | 0.052 | 0.014* | |||
≤ 1.3 cm | 28 | 10 (0–40) | 18% (1–78%) | ||
> 1.3 cm | 22 | 17 (3–153) | 31% (14–77%) | ||
Morphological diagnosis | < 0.001* | < 0.001* | |||
melanocytoma | 7 | 2 (0–4) | 6% (1–18%) | ||
melanoma | 43 | 17 (1–153) | 30% (6–78%) | ||
Prevalent histotype | 0.002* | 0.005* | |||
spindle cell | 8 | 28 (16–153) | 38% (20–54%) | ||
others | 42 | 12 (0–40) | 25% (1–78%) | ||
Junctional activity | 0.005* | 0.026* | |||
present | 17 | 11 (0–27) | 22% (1–61%) | ||
absent | 33 | 21 (0–153) | 32% (2–78%) | ||
Pigmentation | < 0.001* | < 0.001* | |||
≥ 50% | 11 | 3 (0–27) | 8% (1–29%) | ||
< 50% or absent | 39 | 17 (1–153) | 31% (9–78%) | ||
Vascular invasion | 0.353 | 0.565 | |||
present | 7 | 19 (4–36) | 32% (10–47%) | ||
absent | 43 | 13 (0–153) | 27% (1–78%) | ||
Lymphocytic infiltrate | 0.299 | 0.14 | |||
present | 19 | 17 (2–40) | 31% (11–78%) | ||
absent | 31 | 12 (0–153) | 25% (1–68%) | ||
Necrosis | 0.166 | 0.29 | |||
present | 8 | 22 (4–153) | 33% (10–71%) | ||
absent | 42 | 13 (0–48) | 27% (1–78%) | ||