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Table 6 Mean scores of all dogs for cytology scores, microbiological responses, pain and pruritus scores

From: A randomized, controlled, single-blinded, multicenter evaluation of the efficacy and safety of a once weekly two dose otic gel containing florfenicol, terbinafine and betamethasone administered for the treatment of canine otitis externa

  D0 D7 D28 D56
Gel Suspension p-value Gel Suspension p-value Gel Suspension p-value Gel Suspension p-value
Cytology (Mean +/− SD)
 Bacteria 1.7 +/− 0.8 1.7 +/− 0.8 0.7479 n/a n/a n/a 1.1 +/−  0.9 0.9 +/−  0.7 0.2160 1.1 +/− 1.0 0.9 +/− 1.0 0.2233
 Yeasts 2.1 +/− 0.8 2.2 +/− 0.8 0.3957 n/a n/a n/a 1.3 +/− 0.8 1.5 +/− 0.8 0.1077 1.5 +/− 0.9 1.5 +/−  0.9 0.4040
 Neutrophils 1.2 +/− 0.4 1.3 +/− 0.7 0.6431 n/a n/a n/a 0.5 +/− 0.7 0.4 +/− 0.8 0.3488 0.5 +/− 0.7 0.4 +/−  0.9 0.2335
Bacteriological Response (%) n/a n/a n/a     60 60 1.0000 49 55 0.4501
Fungal Response (%) n/a n/a n/a     76 69 0.3318 65 55 0.1824
Investigator Pain Score (est. +/− SE) 1.77 +/− 0.07 1.69 +/− 0.07 0.4406 0.45 +/− 0.05 0.55 +/−  0.05 0.2371 0.38 /−  0.06 0.46 +/−  0.06 0.2967 0.42 +/−  0.06 0.54 +/−  0.07 0.1860
Owner Pain VAS (est. +/− SE) 31.4 +/− 2.8 31.1 +/− 2.9 0.9499 8.3 +/−  0.8 6.8 +/−  0.7 0.1437 3.9 +/−  0.5 3.3 +/−  0.4 0.3984 3.8 +/−  0.5 4.1 +/−  0.6 0.7676
Owner Pruritus VAS (est. +/− SE) 50.2 +/− 3.2 52.5 +/− 3.4 0.6334 10.8 +/− 1.1 7.8 +/−  0.8 0.0232 5.0 +/−  0.6 4.3 +/−  0.6 0.423 5.1 +/−  0.8 5.2 +/−  0.8 0.9208
  1. Est. Estimated, S.E. Standard error, VAS Visual analog scale, SD Standard deviation; Entries in italic font are statistically significant