Comparative single-dose pharmacokinetics of sildenafil after oral and rectal administration in healthy beagle dogs

Table 1 Pharmacokinetic parameters of sildenafil in beagle dogs after administration of each arm

Pharmacokinetic parameters	FCT^a PO 2 mg/kg	ODF^b PO 2 mg/kg	Rectal^c 2 mg/kg	Rectal 10 mg/kg
C_max (μg/mL)	0.21 ± 0.07	0.25 ± 0.10	0.09 ± 0.04	0.26 ± 0.08
T_max (hours)	2.08 ± 1.30	1.88 ± 1.65	3.28 ± 2.49	4.30 ± 2.91
T_1/2 (hours)	5.46 ± 2.39	4.62 ± 1.49	4.82 ± 1.91	4.20 ± 1.40
AUC_last (μg·h/mL)	1.52 ± 0.47	1.51 ± 0.51	0.77 ± 0.31	3.12 ± 1.39

C_max Maximum plasma concentration. T_max Time at the maximum concentration. T_1/2 Elimination half-life. AUC_last Area under the curve from time zero to time of last measurable concentration
^aFCT, Film-coated tablet, ^bODF, orally disintegrating film, ^cRectal, ODF rectal administration

ISSN: 1746-6148