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Table 1 Pharmacokinetic parameters of sildenafil in beagle dogs after administration of each arm

From: Comparative single-dose pharmacokinetics of sildenafil after oral and rectal administration in healthy beagle dogs

Pharmacokinetic parameters FCTa PO
2 mg/kg
ODFb PO
2 mg/kg
Rectalc
2 mg/kg
Rectal
10 mg/kg
Cmax (μg/mL) 0.21 ± 0.07 0.25 ± 0.10 0.09 ± 0.04 0.26 ± 0.08
Tmax (hours) 2.08 ± 1.30 1.88 ± 1.65 3.28 ± 2.49 4.30 ± 2.91
T1/2 (hours) 5.46 ± 2.39 4.62 ± 1.49 4.82 ± 1.91 4.20 ± 1.40
AUClast (μg·h/mL) 1.52 ± 0.47 1.51 ± 0.51 0.77 ± 0.31 3.12 ± 1.39
  1. Cmax Maximum plasma concentration. Tmax Time at the maximum concentration. T1/2 Elimination half-life. AUClast Area under the curve from time zero to time of last measurable concentration
  2. aFCT, Film-coated tablet, bODF, orally disintegrating film, cRectal, ODF rectal administration