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Table 2 Main surveillance parameters with current estimates

From: A new bovine tuberculosis model for England and Wales (BoTMEW) to simulate epidemiology, surveillance and control

Parameter definition

Symbol

Estimate (Range)

S-T range

Source / Derivation

Maximum probability of detecting one infected animal in a herd test using the SICCT skin test

a

0.48

(0.36–0.63)

0.45–0.53

In literature [22, 33] and estimated by fitting. The number of breakdowns disclosed by slaughterhouse surveillance is sensitive to this parameter.

Maximum probability of detecting one infected animal when it is moved from a holding within an area where pre-movement testing is applied.

a m

0.32

(0.24–0.42)

N

Detection reduced by exemptions from pre-movement testing. The recorded number of pre-movement skin tests was about ½ the number of movements from areas with pre-movement testing. Detection > 0.48/2 because infected cattle were more likely to be in movements without exemptions.

Infection duration until SICCT reaches maximum sensitivity

t L

35 (20–200) d

N

Experimental evidence [20].

Specificity of an individual SICCT skin test.

sp Sk

0.9998

N

The estimate of Goodchild et al. [34].

Proportion of age class i that is tested in a regular herd test

w 1

w2..w5

0

0.5–1.0

0

0.50–0.78

Fitted to observed numbers of regular herd tests.

Frequency of generic herd tests on infected herds

g i

Location dependent

0.020–0.09 mth−1

Fitted to observed numbers of breakdowns detected by generic herd tests.

Frequency of generic herd tests on uninfected herds

g u

Location dependent

0.0012–0.04 mth−1

Fitted to observed numbers of generic herd tests.

Maximum probability of detecting an infected animal at slaughterhouse surveillance.

a s

0.875

(0.70–1.00)

0.557–0.875

Estimate may be high because of factors and practices absent from the model, including approved finishing units and age effects [35, 36]. Sensitivity increased during 2008–2010.

Maximum probability of confirming an infected reactor.

a c

0.40

N

Fitted to number of OTFW (confirmed) breakdowns. This value underestimates the number of OTFW animals. (OTFW animals are unevenly distributed among breakdowns.)

Time required for lesions to reach maximum detectability.

t Ls

35 d

(20–200) d

N

This and other models seem to fit using a wide range of values for related parameters [22]. Reports that a high proportion of young reactors have visible lesions indicate a low value [36].

  1. See legend for Table 1. ‘S-T range’, i.e. ‘Spatial-temporal range’ indicates the actual range of values for the parameter used for the baseline fitted model in England and Wales during 2008–2010. ‘N’ indicates that only a single value was used for the parameter