Skip to main content

Table 4 Adverse reactions

From: A randomized placebo-controlled trial of the efficacy and safety of a terbinafine, florfenicol and betamethasone topical ear formulation in dogs for the treatment of bacterial and/or fungal otitis externa

Adverse reactiona Osurnia Placebo
N % of total (n = 190) N % of total (n = 158)
Elevated Alkaline Phosphatase 15 7.9 3 3.2
Vomiting 7 3.7 1 1.1
Elevated AST, ALT, ALPa 2 1.1 0 0.0
Weight Loss (10% BW) 1 0.53 0 0.0
Hearing Decrease/Loss 1 0.53 1 1.1
  1. aAspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP). Two dogs with pre-existing elevations in ALP were reported to have an increase in liver enzymes (ALP, ALT and/or AST) at study exit. Subsequent clinical chemistries returned to normal