Skip to main content

Table 2 Efficacy Study 2: Summary of FMDV Geometric mean virus neutralization titers (GMT) in cattle

From: Efficacy of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine in cattle using a direct contact transmission model

Treatment Group

FMDV A24/Cruzeiro/BRA/55 GMT (± std. dev.; log10)

Days Post-Vaccination/Post Contact Challenge (% seropositive)

7/0

14/7

21/14

24/17

12 T2: 1o Vaccinated and Exposed to 10 IDL challenged seeder cattle for 2–3 days

1.5 ± 0.2** (100%)

1.7 ± 0.2 (100%)

2.0 ± 0.4** (100%)

1.9 ± 0.2** (100%)

6 T3: 1o naïve and Exposed to 10 IDL challenged seeder cattle for 2–3 days

0.6 ± 0.0 (0%)

1.4 ± 0.5 (83%)

2.6 ± 0.2 (100%)

2.8 ± 0.4 (100%)

 

FMDV A24/Cruzeiro/BRA/55 GMT (± std. dev.; log10)

Days Post-Vaccination/Post Contact Challenge (% seropositive)

5/−2

12/5

19/12

22/15

4 T4: 2o Vaccinated; Intermingled with 6 T2: 1o Vaccinated and Exposed cattle in Room 1 for 35 days

0.9 ± 0.2* (75%)

1.5 ± 0.4** (100%)

1.3 ± 0.2** (100%)

1.7 ± 0.4** (100%)

4 T5: 2o naïve; Intermingled with 6 T2: 1o Vaccinated and Exposed cattle in Room 2 for 35 days

0.6 ± 0.0 (0%)

0.6 ± 0.0 (0%)

0.6 ± 0.0 (0%)

0.6 ± 0.0 (0%)

4 T6: 2o naïve; Intermingled with 6 T3: 1o naïve and Exposed cattle in Room 3 for 35 days

0.6 ± 0.0 (0%)

0.6 ± 0.0 (0%)

2.0 ± 0.2** (100%)

2.9 ± 0.3** (100%)

  1. All are two-tailed T-test comparisons within the specified time period
  2. Vaccinated cattle received 5 × 1010 particle units of AdtA24
  3. 1o primary, 2o secondary, IDL intradermolingual challenge
  4. *different at p = 0.05; **different at p ≤ 0.01