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Table 2 Efficacy Study 2: Summary of FMDV Geometric mean virus neutralization titers (GMT) in cattle

From: Efficacy of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine in cattle using a direct contact transmission model

Treatment Group FMDV A24/Cruzeiro/BRA/55 GMT (± std. dev.; log10)
Days Post-Vaccination/Post Contact Challenge (% seropositive)
7/0 14/7 21/14 24/17
12 T2: 1o Vaccinated and Exposed to 10 IDL challenged seeder cattle for 2–3 days 1.5 ± 0.2** (100%) 1.7 ± 0.2 (100%) 2.0 ± 0.4** (100%) 1.9 ± 0.2** (100%)
6 T3: 1o naïve and Exposed to 10 IDL challenged seeder cattle for 2–3 days 0.6 ± 0.0 (0%) 1.4 ± 0.5 (83%) 2.6 ± 0.2 (100%) 2.8 ± 0.4 (100%)
  FMDV A24/Cruzeiro/BRA/55 GMT (± std. dev.; log10)
Days Post-Vaccination/Post Contact Challenge (% seropositive)
5/−2 12/5 19/12 22/15
4 T4: 2o Vaccinated; Intermingled with 6 T2: 1o Vaccinated and Exposed cattle in Room 1 for 35 days 0.9 ± 0.2* (75%) 1.5 ± 0.4** (100%) 1.3 ± 0.2** (100%) 1.7 ± 0.4** (100%)
4 T5: 2o naïve; Intermingled with 6 T2: 1o Vaccinated and Exposed cattle in Room 2 for 35 days 0.6 ± 0.0 (0%) 0.6 ± 0.0 (0%) 0.6 ± 0.0 (0%) 0.6 ± 0.0 (0%)
4 T6: 2o naïve; Intermingled with 6 T3: 1o naïve and Exposed cattle in Room 3 for 35 days 0.6 ± 0.0 (0%) 0.6 ± 0.0 (0%) 2.0 ± 0.2** (100%) 2.9 ± 0.3** (100%)
  1. All are two-tailed T-test comparisons within the specified time period
  2. Vaccinated cattle received 5 × 1010 particle units of AdtA24
  3. 1o primary, 2o secondary, IDL intradermolingual challenge
  4. *different at p = 0.05; **different at p ≤ 0.01