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Table 6 Mean (CV%) pharmacokinetic parameters by group for robenacoxib administered orally once daily for 6 months at 3 dose levels

From: Six-month safety evaluation of robenacoxib tablets (Onsior™) in dogs after daily oral administrations

Group (Dose) Day Cmax (ng/mL) AUClast (h x ng/mL) Tmax (h)
2 (2 mg/kg) 1 1888 (55) 2091 (23) 1.03 (64)
30 1384 (51) 2042 (32) 1.06 (58)
150 5277 (45) 6629 (45) 0.94 (19)
3 (6 mg/kg) 1 4255 (51) 8626 (53) 1.28 (63)
30 5940 (55) 9700 (24) 1.13 (51)
150 4146 (64) 7602 (44) 0.81 (32)
4 (10 mg/kg) 1 6612 (44) 15,246 (35) 1.88 (19)
30 5877 (39) 13,803 (22) 1.25 (52)
150 4777 (36) 11,077 (32) 1.25 (52)