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Table 5 Summary of body (kg) and organ (g) weights; mean (SD), N = 8 unless stated

From: Six-month safety evaluation of robenacoxib tablets (Onsior™) in dogs after daily oral administrations

Organ Group 1 (sham) Group 2 (2 mg/kg) Group 3 (6 mg/kg) Group 4 (10 mg/kg) P-value1 Treatment
Body weight 11.23 (2.43) 11.31 (2.28) 11.18 (1.69) 10.78 (1.68) 0.8599
Adrenal glands 1.05 (0.15) 1.10 (0.21) 1.09 (0.17) 1.09 (0.16) 0.9364
Brain 75.69 (6.15) 77.12 (4.93) 78.50 (7.30) 74.62 (4.03) 0.4629
Epididymides (N = 4) 3.70 (0.92) 3.82 (0.42) 4.35 (0.63) 3.90 (0.30) 0.4915
Heart 86.57 (19.57) 84.26 (13.63) 85.48 (18.00) 84.51 (17.31) 0.9714
Kidneys 54.25 (13.40) 50.60 (8.81) 49.37 (11.02) 53.59 (14.19) 0.5232
Liver 316.83 (58.45) 323.03 (37.76) 303.03 (55.02) 298.05 (60.58) 0.6478
Lung 90.49 (16.43) 87.50 (12.44) 87.09 (14.23) 90.07 (13.05) 0.7920
Ovaries (N = 4) 1.86 (0.51) 1.88 (0.22) 1.29 (0.30) 1.14 (0.41) 0.0319
Pituitary glands 0.07 (0.01) 0.07 (0.02) 0.07 (0.01) 0.08 (0.02) 0.3945
Salivary gland 5.45 (1.43) 5.36 (0.99) 5.69 (1.08) 5.14 (1.16) 0.8261
Spleen 50.93 (15.95) 69.04 (15.92) 52.13 (20.22) 71.59 (20.26) 0.0131
Testes (N = 4) 13.35 (4.02) 17.37 (3.19) 16.36 (4.48) 17.91 (2.86) 0.3470
Thymus gland 6.39 (3.49) 7.47 (3.34) 7.72 (3.62) 5.43 (1.77) 0.4936
Thyroid/parathyroid glands 0.87 (0.20) 0.88 (0.19) 0.89 (0.18) 1.00 (0.16) 0.4457
  1. Footnote:
  2. 1 P-values in bold denote significance