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Table 4 Summary data of histology

From: Six-month safety evaluation of robenacoxib tablets (Onsior™) in dogs after daily oral administrations

Tissue Group 1 (sham) Group 2 (2 mg/kg) Group 3 (6 mg/kg) Group 4 (10 mg/kg)
Observation, severity (localization)
Adrenal glands
 Normal 8 8 8 8
Aorta
 Normal 8 8 8 8
Bone marrow
 Normal (femur) 8 8 8 8
 Normal (rib) 8 8 8 8
 Normal (sternum) 8 8 8 8
Bone
 Normal (femur) 7 7 8 8
 Cartilage degeneration, minimal (femur) 1 1 0 0
 Normal (rib) 8 8 8 8
 Normal (sternum) 8 8 8 8
Brain
 Normal 7 8 8 8
 Gliosis, minimal 1 0 0 0
Eyes, optic nerves
 Normal 8 8 8 8
Gallbladder
 Normal 8 8 8 8
Gastronintestinal tract
 Normal (esophagus) 8 8 8 8
 Normal (stomach) 8 8 8 7
 Focal mineralization, minimal (stomach, cardia) 0 0 0 1
 Normal (duodenum) 8 8 8 8
 Normal (ileum) 8 8 7 8
 Mucosal atrophy, minimal (ileum) 0 0 1 0
 Normal (jejunum) 8 8 8 8
 Normal (cecum) 8 8 8 8
 Normal (colon) 7 8 8 8
 Cyst, mild (colon) 1 0 0 0
 Normal (rectum) 8 8 8 8
Gonads
 Normal (ovaries) 4 4 4 4
 Normal (testis) 2 4 3 3
 Seminiferous tubules hypoplasia, minimal (testis) 2 0 1 1
 Hypospermatogenesis, moderate (testis) 1 0 0 0
Heart
 Normal 7 8 8 8
 Hematocyst, minimal (valvular) 1 0 0 0
Kidneys
 Normal 0 1 0 0
 Lymphocytic infiltration, minimal 0 1 1 0
 Tubular mineralization, minimal 8 7 8 8
 Tubular regeneration, minimal 1 0 0 0
Liver
 Normal 8 7 7 4
 Mononuclear infiltrate, minimal 0 1 1 4
Lung
 Normal 0 1 2 1
 Hemorrhage, minimal 0 0 0 1
 Alveolar histiocytosis, minimal or mild 6 6 4 5
 Lymphocytic infiltration, minimal 6 3 3 3
 Subacture inflammation, minimal 0 0 2 0
Lymph nodes
 Normal (mandibular) 8 8 8 8
 Normal (mesenteric) 8 8 8 8
 Normal (tracheobronchial) 8 8 8 8
Pancreas
 Normal 7 8 8 8
 Lymphocytic infiltration, minimal 1 8 8 8
Pituitary
 Normal 6 8 6 7
 Cyst, minimal or mild 2 0 2 1
Prostate
 Normal 4 4 1 4
 Lymphocitic infiltration, minimal or mild 0 0 3 0
Salivary gland
 Normal 6 7 6 8
 Lymphocytic infiltration, minimal 2 1 2 0
Skeletal muscle
 Normal 8 8 8 8
Skin
 Normal 8 8 8 8
Spinal cord (cervical, thoracic and lumbar)
 Normal 8 8 8 8
Spleen
 Normal 8 8 8 8
Thymus
 Normal 0 0 1 1
 Cyst, minimal or mild 2 4 0 3
 Lymphoid depletion, minimal to moderate 8 8 7 6
Thyroid
 Normal 8 8 8 8
Trachea
 Normal 8 8 8 8
Urinary bladder
 Normal 8 8 8 8
Uterus with cervix
 Normal 3 3 4 4
 Cyst, mild 1 0 0 0
 Pseudocyesis, mild 0 1 0 0
Vagina
 Normal 8 8 8 8
  1. Data are the number of dogs with presence of normal histology or detected abnormalities
  2. N = 8 per group (4 males and 4 females)