Table 3 Summary of clinical chemistry data; mean (SD), N = 8
Variable (reference range and units)a | Day | Group 1 (sham) | Group 2 (2 mg/kg) | Group 3 (6 mg/kg) | Group 4 (10 mg/kg) | P-value2 |
|---|---|---|---|---|---|---|
Treatment | ||||||
Alkaline phosphatase (1–114 U/L) | Pretest | 89.3 (25.9) | 101.5 (21.9) | 86.4 (11.5) | 94.4 (16.1) | 0.8687 |
30 | 76.8 (28.7) | 82.9 (16.8) | 70.0 (10.6) | 79.3 (15.0) | ||
91 | 47.9 (17.6) | 53.5 (14.2) | 45.1 (10.9) | 50.6 (8.5) | ||
181 | 36.6 (17.1) | 41.8 (15.3) | 36.1 (6.0) | 42.1 (8.6) | ||
Aspartate aminotransferase (28–60 U/L) | Pretest | 35.1 (5.3) | 35.5 (5.3) | 38.1 (8.3) | 36.1 (9.5) | 0.7180 |
30 | 31.1 (6.8) | 30.3 (6.2) | 30.1 (4.0) | 30.4 (3.8) | ||
91 | 30.4 (5.5) | 34.8 (3.8) | 31.3 (5.4) | 26.8 (3.5) | ||
181 | 27.9 (8.6) | 27.1 (5.3) | 27.8 (4.7) | 28.8 (3.7) | ||
Alanine aminotransferase (10–109 U/L) | Pretest | 27.6 (5.0) | 28.8 (4.1) | 28.4 (7.8) | 28.6 (7.2) | 0.8099 |
30 | 30.6 (7.1) | 29.4 (5.6) | 32.6 (5.8) | 29.3 (3.5) | ||
91 | 30.5 (6.6) | 36.0 (10.1) | 31.9 (5.1) | 34.1 (12.9) | ||
181 | 32.3 (12.8) | 29.0 (7.0) | 33.6 (9.5) | 37.6 (12.8) | ||
Creatine kinase (52–368 U/L) | Pretest | 312.1 (153.0) | 261.8 (98.7) | 278.8 (52.5) | 324.4 (228.5) | 0.7749 |
30 | 216.5 (57.9) | 186.8 (56.5) | 182.1 (26.6) | 211.4 (40.8) | ||
91 | 185.8 (38.8) | 248.3 (153.8) | 182.3 (44.3) | 163.8 (41.6) | ||
181 | 197.1 (81.3) | 174.4 (55.3) | 180.9 (59.0) | 179.1 (45.8) | ||
Urea nitrogen (8–28 mg/dL) | Pretest | 11.0 (2.6) | 11.5 (1.6) | 11.4 (2.1) | 11.1 (1.9) | 0.5554 |
30 | 13.8 (2.8) | 13.3 (1.6) | 13.4 (2.3) | 13.8 (1.8) | ||
91 | 15.3 (1.9) | 15.0 (2.8) | 14.1 (2.9) | 13.0 (2.4) | ||
181 | 15.1 (2.4) | 15.5 (2.5) | 14.3 (2.8) | 15.6 (1.8) | ||
Creatinine (0.5–1.7 mg/dL) | Pretest | 0.59 (0.08) | 0.60 (0.05) | 0.59 (0.04) | 0.58 (0.07) | 0.8214 |
30 | 0.70 (0.14) | 0.69 (0.06) | 0.66 (0.07) | 0.68 (0.07) | ||
91 | 0.73 (0.10) | 0.74 (0.07) | 0.69 (0.08) | 0.69 (0.10) | ||
181 | 0.76 (0.14) | 0.74 (0.09) | 0.74 (0.05) | 0.74 (0.07) | ||
Total Protein (5.4–7.5 g/dL) | Pretest | 5.83 (0.20) | 5.56 (0.17) | 5.75 (0.31) | 5.68 (0.27) | 0.6166 |
30 | 5.90 (0.26) | 5.61 (0.11) | 5.76 (0.36) | 5.75 (0.25) | ||
91 | 5.69 (0.16) | 5.46 (0.15) | 5.55 (0.40) | 5.60 (0.23) | ||
181 | 6.46 (0.14) | 6.19 (0.14) | 6.23 (0.38) | 6.25 (0.30) | ||
Albumin (2.9–3.9 g/dL) | Pretest | 3.34 (0.16) | 3.18 (0.12) | 3.20 (0.15) | 3.21 (0.10) | 0.0631 |
30 | 3.24 (0.17) | 3.08 (0.15) | 3.09 (0.16) | 3.19 (0.16) | ||
91 | 3.48 (0.15) | 3.35 (0.12) | 3.24 (0.19) | 3.36 (0.11) | ||
181 | 3.64 (0.12) | 3.31 (0.12) | 3.31 (0.22) | 3.45 (0.13) | ||
Direct bilirubin (0.0–0.3 mg/dL) | Pretest | (−) | (−) | (−) | (−) | 0.4098 |
30 | 0.00 (0.00) | 0.01 (0.04) | 0.00 (0.00) | 0.04 (0.05) | ||
91 | 0.04 (0.05) | 0.00 (0.00) | 0.03 (0.05) | 0.00 (0.00) | ||
181 | 0.01 (0.04) | 0.00 (0.00) | 0.01 (0.04) | 0.01 (0.04) | ||
Cholesterol (135–278 mg/dL) | Pretest | 164.3 (30.1) | 145.8 (24.3) | 155.5 (22.5) | 158.6 (23.1) | 0.1893 |
30 | 156.6 (26.6) | 136.5 (19.2) | 142.4 (14.7) | 146.0 (18.0) | ||
91 | 153.1 (41.3) | 131.1 (18.6) | 133.9 (12.1) | 147.4 (24.8) | ||
181 | 194.4 (54.2) | 186.1 (55.0) | 177.1 (37.6) | 158.0 (30.4) | ||
Calcium (9.1–11.7 mg/dL) | Pretest | 11.01 (0.33) | 10.73 (0.21) | 10.86 (0.26) | 10.91 (0.26) | 0.0423 |
30 | 11.03 (0.28) | 10.93 (0.18) | 10.85 (0.26) | 10.99 (0.27) | ||
91 | 10.54 (0.15) | 10.46 (0.09) | 10.30 (0.20) | 10.46 (0.31) | ||
181 | 10.86 (0.37) | 10.74 (0.11) | 10.69 (0.18) | 10.88 (0.23) |