Table 2 Summary of hematology data; mean (SD), N = 8
Variable (reference range and units)a | Day | Group 1 (sham) | Group 2 (2 mg/kg) | Group 3 (6 mg/kg) | Group 4 (10 mg/kg) | P-value2 |
|---|---|---|---|---|---|---|
Treatment | ||||||
White blood cell count (5.0–14.1 × 103/μL) | Pretest | 12.25 (2.10) | 12.81 (2.53) | 15.81 (5.14) | 13.88 (4.39) | 0.2703 |
30 | 9.91 (0.95) | 12.29 (2.72) | 11.74 (2.51) | 11.31 (1.71) | ||
91 | 10.15 (1.80) | 10.45 (1.36) | 12.83 (2.69) | 12.46 (3.96) | ||
181 | 9.34 (2.25) | 11.03 (4.63) | 11.30 (1.81) | 10.59 (1.99) | ||
Red blood cell count (4.95–7.87 × 106/μL) | Pretest | 7.079 (0.396) | 7.344 (0.407) | 6.994 (0.582) | 6.935 (0.597) | 0.7588 |
30 | 7.124 (0.570) | 7.169 (0.677) | 6.940 (0.492) | 6.910 (0.357) | ||
91 | 7.103 (0.411) | 7.590 (0.701) | 6.995 (0.448) | 6.984 (0.534) | ||
181 | 6.835 (0.380) | 6.880 (0.538) | 6.633 (0.389) | 6.948 (0.289) | ||
Reticulocytes (< 80 × 103/μL) | Pretest | 42.70 (14.25) | 51.36 (35.09) | 45.20 (13.76) | 42.90 (13.09) | 0.0962 |
30 | 32.89 (14.74) | 40.03 (16.68) | 47.28 (16.49) | 35.43 (12.29) | ||
91 | 13.73 (8.39) | 22.65 (9.31) | 26.43 (15.38) | 22.76 (8.48) | ||
181 | 28.48 (24.78) | 21.51 (8.90) | 41.43 (18.70) | 30.53 (15.87) | ||
Eosinophils (0.0–1.3 × 103/μL) | Pretest | 0.226 (0.062) | 0.278 (0.179) | 0.270 (0.097) | 0.358 (0.102) | 0.0005 |
30 | 0.248 (0.122) | 0.265 (0.137) | 0.291 (0.095) | 0.453 (0.141) | ||
91 | 0.228 (0.057) | 0.274 (0.115) | 0.288 (0.089) | 0.465 (0.207) | ||
181 | 0.276 (0.073) | 0.301 (0.112) | 0.340 (0.109) | 0.598 (0.176) | ||
Platelets (211–621 × 103/μL) | Pretest | 333.5 (52.7) | 311.9 (49.7) | 269.3 (63.1) | 300.3 (46.4) | 0.8921 |
30 | 346.8 (81.4) | 333.9 (36.1) | 295.9 (90.0) | 315.8 (37.3) | ||
91 | 313.9 (62.7) | 313.3 (61.6) | 301.5 (68.4) | 306.4 (54.4) | ||
181 | 301.3 (84.0) | 298.6 (63.8) | 269.0 (90.2) | 277.1 (41.5) | ||
Hemoglobin (11.9–18.9 g/dL) | Pretest | 15.54 (0.73) | 15.70 (0.85) | 15.49 (1.28) | 15.04 (1.30) | 0.8821 |
30 | 16.09 (1.00) | 15.90 (1.02) | 15.88 (1.13) | 15.49 (1.20) | ||
91 | 15.60 (0.66) | 16.68 (1.35) | 15.69 (1.00) | 15.45 (1.26) | ||
181 | 15.76 (0.79) | 15.53 (1.21) | 15.45 (0.92) | 15.93 (0.61) | ||
Hematocrit (35–57%) | Pretest | 43.94 (2.12) | 44.86 (2.46) | 43.63 (3.66) | 42.56 (3.51) | 0.8776 |
30 | 45.11 (3.16) | 44.45 (2.98) | 44.31 (3.31) | 43.20 (2.89) | ||
91 | 44.05 (2.95) | 46.68 (4.00) | 43.66 (2.86) | 42.63 (4.16) | ||
181 | 42.65 (2.40) | 42.53 (3.36) | 41.71 (2.28) | 43.19 (1.57) |