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Table 2 Summary of hematology data; mean (SD), N = 8

From: Six-month safety evaluation of robenacoxib tablets (Onsior™) in dogs after daily oral administrations

Variable (reference range and units)a Day Group 1 (sham) Group 2 (2 mg/kg) Group 3 (6 mg/kg) Group 4 (10 mg/kg) P-value2
Treatment
White blood cell count (5.0–14.1 × 103/μL) Pretest 12.25 (2.10) 12.81 (2.53) 15.81 (5.14) 13.88 (4.39) 0.2703
30 9.91 (0.95) 12.29 (2.72) 11.74 (2.51) 11.31 (1.71)
91 10.15 (1.80) 10.45 (1.36) 12.83 (2.69) 12.46 (3.96)
181 9.34 (2.25) 11.03 (4.63) 11.30 (1.81) 10.59 (1.99)
Red blood cell count (4.95–7.87 × 106/μL) Pretest 7.079 (0.396) 7.344 (0.407) 6.994 (0.582) 6.935 (0.597) 0.7588
30 7.124 (0.570) 7.169 (0.677) 6.940 (0.492) 6.910 (0.357)
91 7.103 (0.411) 7.590 (0.701) 6.995 (0.448) 6.984 (0.534)
181 6.835 (0.380) 6.880 (0.538) 6.633 (0.389) 6.948 (0.289)
Reticulocytes (< 80 × 103/μL) Pretest 42.70 (14.25) 51.36 (35.09) 45.20 (13.76) 42.90 (13.09) 0.0962
30 32.89 (14.74) 40.03 (16.68) 47.28 (16.49) 35.43 (12.29)
91 13.73 (8.39) 22.65 (9.31) 26.43 (15.38) 22.76 (8.48)
181 28.48 (24.78) 21.51 (8.90) 41.43 (18.70) 30.53 (15.87)
Eosinophils (0.0–1.3 × 103/μL) Pretest 0.226 (0.062) 0.278 (0.179) 0.270 (0.097) 0.358 (0.102) 0.0005
30 0.248 (0.122) 0.265 (0.137) 0.291 (0.095) 0.453 (0.141)
91 0.228 (0.057) 0.274 (0.115) 0.288 (0.089) 0.465 (0.207)
181 0.276 (0.073) 0.301 (0.112) 0.340 (0.109) 0.598 (0.176)
Platelets (211–621 × 103/μL) Pretest 333.5 (52.7) 311.9 (49.7) 269.3 (63.1) 300.3 (46.4) 0.8921
30 346.8 (81.4) 333.9 (36.1) 295.9 (90.0) 315.8 (37.3)
91 313.9 (62.7) 313.3 (61.6) 301.5 (68.4) 306.4 (54.4)
181 301.3 (84.0) 298.6 (63.8) 269.0 (90.2) 277.1 (41.5)
Hemoglobin (11.9–18.9 g/dL) Pretest 15.54 (0.73) 15.70 (0.85) 15.49 (1.28) 15.04 (1.30) 0.8821
30 16.09 (1.00) 15.90 (1.02) 15.88 (1.13) 15.49 (1.20)
91 15.60 (0.66) 16.68 (1.35) 15.69 (1.00) 15.45 (1.26)
181 15.76 (0.79) 15.53 (1.21) 15.45 (0.92) 15.93 (0.61)
Hematocrit (35–57%) Pretest 43.94 (2.12) 44.86 (2.46) 43.63 (3.66) 42.56 (3.51) 0.8776
30 45.11 (3.16) 44.45 (2.98) 44.31 (3.31) 43.20 (2.89)
91 44.05 (2.95) 46.68 (4.00) 43.66 (2.86) 42.63 (4.16)
181 42.65 (2.40) 42.53 (3.36) 41.71 (2.28) 43.19 (1.57)
  1. Footnote:
  2. a These reference ranges are to be used for information only and the pretest values collected before the dosing period during acclimatization should be used for interpretation in the context of this study
  3. 2 P-values in bold denote significance