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Table 2 Immunoreactivity of squamous cell carcinomas (SCCs) in three reptiles [a bearded dragon (Pogona vitticeps) and two loggerhead sea turtles (Caretta caretta)] with commercially available monoclonal anti-alpha human keratin AE1 and AE3 antibodies

From: Immunohistochemical staining patterns of alpha-keratins in normal tissues from two reptile species: implications for characterization of squamous cell carcinomas

 

Pogona vitticeps

C. caretta #1a

C. caretta # 2b

AE1

AE3

AE1

AE3

AE1

AE3

Cutaneous SCC nests

 Basal layer

+++

+

+++

+++

+++

+++

 Suprabasal (intermediate) layer

+++

+

+++

+++

+++

+++

 Keratin pearls (cornified layer)

+++

Invasive neoplastic cords (dermis)

  

+++

+++

+++

+++

Metastases

 Myocardium

  

+++

++/−c

+++

 Lung

  

+++

++/−d

+++

 Kidney

  

+++

++/−d

+++

 Spleen

    

+++

 Liver

    

+++

 Muscle tissue

    

+++

  1. Reactivity was judged as intense (+++), moderate (++), weak (+), negative (−), or variable (weak/negative) (+/−), respectively
  2. aWell-differentiated metastatic cutaneous SCC
  3. bPoorly differentiated metastatic cutaneous SCC
  4. cOnly the biggest metastatic foci showed immunoreactivity (limited to suprabasal and pre-cornified layers)
  5. dReactivity was detected in a few metastases showing stratified squamous differentiation