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Table 2 Median (IQR)d of histological assessment among ES, ED and G at 4 years post-engraftment

From: Sheep embryonic stem-like cells engrafted into sheep femoral condyle osteochondral defects: 4-year follow-up

Categories

ES a

ED b

G c

P-value

Filling od defect

2.0 (1.0–2.0)

1.5 (1.0–2.0)

1.0 (0.5–1.0)

0.19

Cartilage

10.0 (6.5–10.0)

8.5 (5.5–11.0)

7.5 (6.0–8.5)

0.62

Bone

7.0 (5.0–7.5)

5.5 (4.5–6.0)

6.0 (5.5–6.5)

0.39

Edges

1.5 (0.0–4.0)

0.5 (0.0–2.0)

1.0 (0.0–1.0)

0.73

Vascularity

6.0 (4.0–8.0)

4.5 (4.5–5.5)

3.5 (2.0–5.0)

0.25

Degeneration

7.5 (7.0–8.0)

7.0 (5.0–7.5)

7.0 (6.5–8.0)

0.53

Matrix staining

6.5 (1.5–8.5)

6.0 (4.0–8.0)

2.5 (1.5–4.5)

0.36

total score

45.5 (28.0–47.5)

35.5 (30.0–41.0)

33.5 (26.0–34.0)

0.39

  1. aembryonic stem-like cells engrafted in the osteochondral defect created in the left medial femoral condyle; b empty defect created in the right medial condyle and left untreated; c: glue filling in the osteochondral defect created in the right lateral condyle
  2. dIQR: inter-quartile range