Table 1 Comparative characteristics of cutaneous lupus erythematosus variants in dogs
From: Cutaneous lupus erythematosus in dogs: a comprehensive review
| Â | SCLE | CCLE | |||
|---|---|---|---|---|---|
VCLE | ECLE | MCLE | FDLE | GDLE | |
Most commonly affected breeds | Shetland sheepdogs, rough collies and border collies | German shorthaired pointers and Magyar viszlas | German shepherd dogs | German shepherd dogs | Chinese crested dogs |
Ages of onset: median (range) | 5.5 (2.0–11.0) | 0.7 (0.2–3.5) | 6.0 (3.0–13.0) | 7.0 (1.0–12.0) | 9.0 (5.0–12.0) |
female-to-male ratios | 0.9 | 1.4 | 1.8 | 0.7 | 1.0 |
Most common skin lesions | figurate erythema, flaccid vesicles and erosions | erythema, scaling, follicular casts, alopecia and occasional scarring | erosions, ulcers with or without peripheral hyperpigmentation | dyspigmentation, erythema, erosions, ulcers, scaling crusting, | dyspigmentation, erythema, erosions, ulcers, scaling, crusting |
Most common lesion distribution | abdomen, axillae, medial thighs, concave pinnae and perimucosal areas | trunk, muzzle, pinnae and abdomen | genital, perigenital, anal, perianal, periocular and perilabial areas | nasal planum and dorsal muzzle | trunk, lateral legs and abdomen |
Systemic signs | typically not seen | lymphadenomegaly, arthralgia, and reproductive defects | typically not seen | typically not seen | typically not seen |
Most relevant clinical mimics | erythema multiforme | sebaceous adenitis | mucocutaneous pyoderma, mucous membrane pemphigoid and erythema multiforme variants | mucocutaneous pyoderma, epitheliotropic cell lymphoma and uveodermatological syndrome | hyperkeratotic erythema multiforme and generalized ischemic dermatopathies |