Fig. 8

Histopathology of canine mucocutaneous lupus erythematosus. a: cell-rich, lymphocytic interface dermatitis is present with numerous plasma cells, including Mott cells, which is common with inflammation in perimucosal skin and is exacerbated by secondary bacterial infection. 100X (b): inset box from image “a”, lymphocytes infiltrate the basal and suprabasal layers of the epidermis in association with multifocal basal cell apoptosis. 400X (c): basement membrane thickening (arrows) is present and is usually patchy and multifocal. 400X (d): lymphocytic interface folliculitis and mural folliculitis involve the infundibulum and extend to the isthmus (not shown) of a hair follicle. 400X (e): lymphocytic mural folliculitis of the inferior hair follicle (external root sheath), with apoptosis and follicular atrophy. 200X