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Table 7 Lesion score (Mean ± SE) for histopathological changes in kidneys during sub-chronic L. camara toxicity in guinea pigs

From: Sub-chronic toxicopathological study of lantadenes of Lantana camara weed in Guinea pigs

Group

Necrosis

Fibrosis

Degenerative change

Inflammatory change

Hyaline casts formation

Epithelial casts formation

Apoptosis

GI

2.33 ± 0.21c

2.00 ± 0.26c

2.50 ± 0.22c

2.17 ± 0.31b

2.83 ± 0.17c

2.67 ± 0.21c

1.67 ± 0.21b

GII

2.00 ± 0.26bc

1.50 ± 0.22bc

2.50 ± 0.22c

1.83 ± 0.31b

2.50 ± 0.22bc

2.33 ± 0.21bc

1.00 ± 0.37ab

GIII

1.17 ± 0.31abc

0.83 ± 0.17abc

1.33 ± 0.21abc

1.17 ± 0.31ab

1.50 ± 0.34abc

1.17 ± 0.31abc

0.83 ± 0.17ab

G1V

0.67 ± 0.21ab

0.33 ± 0.21ab

0.67 ± 0.21ab

0.83 ± 0.31ab

0.50 ± 0.22ab

0.50 ± 0.22ab

1.00 ± 0.26ab

GV

0.00 ± 0.00a

0.00 ± 0.00a

0.00 ± 0.00a

0.00 ± 0.00a

0.00 ± 0.00a

0.00 ± 0.00a

0.00 ± 0.00a

  1. a-cValues within columns with different superscripts differ significantly by ANOVA (P ≤ 0.05). GI = Lantadenes @ 24 mg/kg bw; GII = Lantadenes @ 18 mg/kg bw; GIII = Lantadenes @ 12 mg/kg bw; GIV = Lantadenes @ 6 mg/kg bw; GV = control group, n = 6