Sub-chronic toxicopathological study of lantadenes of Lantana camara weed in Guinea pigs

Table 6 Lesion score (Mean ± SE) for histopathological changes in liver during sub-chronic L. camara toxicity in guinea pigs

Group	Necrosis	Fibrosis	Bile duct proliferation	Increased Kupffer cell activity	Inflammatory change	Apoptosis	Degenerative change	Regenerative change
GI	2.00 ± 0.26^a	1.67 ± 0.21^b	1.50 ± 0.34^b	2.50 ± 0.22^c	1.83 ± 0.31^b	1.33 ± 0.21^bc	1.67 ± 0.21^b	2.17 ± 0.31^b
GII	1.33 ± 0.33^ab	1.50 ± 0.22^b	1.33 ± 0.21^b	1.67 ± 0.21^bc	1.67 ± 0.21 ^b	1.83 ± 0.17 ^c	1.33 ± 0.21^b	1.67 ± 0.21 ^b
GIII	1.17 ± 0.31^ab	0.83 ± 0.17^ab	1.00 ± 0.26^ab	1.17 ± 0.17^abc	1.17 ± 0.31^ab	1.00 ± 0.26^abc	1.00 ± 0.26^ab	1.33 ± 0.21^ab
G1V	0.67 ± 0.21^ab	0.67 ± 0.21^ab	0.50 ± 0.22^ab	0.67 ± 0.21^ab	0.67 ± 0.21^ab	0.33 ± 0.21^ab	0.83 ± 0.31^ab	1.00 ± 0.26^ab
GV	0.00 ± 0.00^a	0.00 ± 0.00^a	0.00 ± 0.00^a	0.00 ± 0.00^a	0.00 ± 0.00^a	0.00 ± 0.00^a	0.00 ± 0.00^a	0.00 ± 0.00^a

^a-cValues within columns with different superscripts differ significantly by ANOVA (P ≤ 0.05). GI = Lantadenes @ 24 mg/kg bw; GII = Lantadenes @ 18 mg/kgbw; GIII = Lantadenes @ 12 mg/kg bw; GIV = Lantadenes @ 6 mg/kg bw; GV = control group, n = 6