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Table 6 Lesion score (Mean ± SE) for histopathological changes in liver during sub-chronic L. camara toxicity in guinea pigs

From: Sub-chronic toxicopathological study of lantadenes of Lantana camara weed in Guinea pigs

Group Necrosis Fibrosis Bile duct proliferation Increased Kupffer cell activity Inflammatory change Apoptosis Degenerative change Regenerative change
GI 2.00 ± 0.26a 1.67 ± 0.21b 1.50 ± 0.34b 2.50 ± 0.22c 1.83 ± 0.31b 1.33 ± 0.21bc 1.67 ± 0.21b 2.17 ± 0.31b
GII 1.33 ± 0.33ab 1.50 ± 0.22b 1.33 ± 0.21b 1.67 ± 0.21bc 1.67 ± 0.21 b 1.83 ± 0.17 c 1.33 ± 0.21b 1.67 ± 0.21 b
GIII 1.17 ± 0.31ab 0.83 ± 0.17ab 1.00 ± 0.26ab 1.17 ± 0.17abc 1.17 ± 0.31ab 1.00 ± 0.26abc 1.00 ± 0.26ab 1.33 ± 0.21ab
G1V 0.67 ± 0.21ab 0.67 ± 0.21ab 0.50 ± 0.22ab 0.67 ± 0.21ab 0.67 ± 0.21ab 0.33 ± 0.21ab 0.83 ± 0.31ab 1.00 ± 0.26ab
GV 0.00 ± 0.00a 0.00 ± 0.00a 0.00 ± 0.00a 0.00 ± 0.00a 0.00 ± 0.00a 0.00 ± 0.00a 0.00 ± 0.00a 0.00 ± 0.00a
  1. a-cValues within columns with different superscripts differ significantly by ANOVA (P ≤ 0.05). GI = Lantadenes @ 24 mg/kg bw; GII = Lantadenes @ 18 mg/kgbw; GIII = Lantadenes @ 12 mg/kg bw; GIV = Lantadenes @ 6 mg/kg bw; GV = control group, n = 6