Skip to main content

Table 2 Mucosal S100A12 and MPO levels in relation to histopathologic changes in the colon and cecum

From: S100A12 concentrations and myeloperoxidase activities are increased in the intestinal mucosa of dogs with chronic enteropathies

Histopathological findings

n

Severity groups

S100A12 (μg/L)

Median (IQR)

P valuea

MPO (ΔA/min)

Median (IQR)

P valuea

Colon

15

     

 Total histopathological severity

15

Insignificant (n = 7)

49.01 (10.8-184.68)

0.0274 b

1.04 (0.22-3.37)

0.1280

Mild (n = 7)

111.4 (32.81-538.8)

1.49 (0.38-4.08)

Moderate (n = 1)

1296.65

6.61

Morphological criteria

15

     

 Epithelial injury

15

Normal (n = 8)

44.18 (10.8-184.68)

0.0083 b

1.28 (0.22-4.08)

0.4232

Mild (n = 3)

254.57 (89.16-536.8)

1.49 (0.57-2.59)

Moderate (n = 3)

111.4 (32.81-211.53)

0.68 (0.38-3.01)

Severe (n = 1)

1296.65

6.61

 Crypt hyperplasia

15

Normal (n = 11)

89.61 (10.8-536.8)

0.8412

1.1 (0.22-3.37)

0.3437

Mild (n = 3)

33.53 (32.81-1296.65)

1.46 (0.68-6.61)

Moderate (n = 1)

44.9

4.08

 Crypt dilation and distorsion

15

Normal (n = 12)

76.01 (10.8-536.8)

0.5706

1.48 (0.22-4.08)

0.5858

Mild (n = 3)

49.01 (32.81-1296.65)

1.1 (0.68-6.61)

 Mucosal fibrosis and atrophy

15

Normal (n = 8)

53.97 (10.8-1296.65)

0.4267

0.86 (0.22-6.61)

0.9124

Mild (n = 5)

111.4 (43.45-254.57)

2.59 (0.38-3.37)

Moderate (n = 1)

536.8

1.49

Severe (n = 1)

33.53

1.46

Inflammatory criteria

15

     

 Lamina propria LPC

15

Normal (n = 2)

312.98 (89.16-536.8)

0.0554

1.03 (0.57-1.49)

0.4088

Mild (n = 9)

49.01 (22.89-211.53)

1.1 (0.22-3.37)

Moderate (n = 3)

44.9 (10.8-254.57)

2.59 (0.28-4.08)

Severe (n = 1)

1296.65

6.61

 Lamina propria eosinophils

15

Normal (n = 9)

63.04 (10.8-254.57)

0.1076

1.04 (0.22-3.37)

0.1516

Mild (n = 3)

33.53 (22.89-89.16)

1.46 (0.57-2.04)

Moderate (n = 3)

536.8 (44.9-1296.65)

4.08 (1.49-6.61)

 Lamina propria neutrophils

15

Normal (n = 10)

46.96 (10.8-1296.65)

0.2448

1.07 (0.22-6.61)

0.9400

Mild (n = 4)

161.47 (33.53-254.57)

2.02 (0.38-3.01)

Moderate (n = 1)

536.8

1.49

 Lamina propria macrophage

15

Normal (n = 15)

63.04 (10.8-1296.65)

–

1.46 (0.22-6.61)

–

Cecum

6

     

 Total histopathological severity

6

Insignificant (n = 6)

160.38 (8.62-405.48)

–

0.68 (0.12-1.66)

–

Morphological criteria

6

     

 Epithelial injury

6

Normal (n = 3)

34.02 (8.62-249.74)

0.2187

0.37 (0.12-1.66)

0.4642

Mild (n = 3)

351.79 (71.02-405.48)

0.97 (0.4-1.51)

 Crypt hypeplasia

6

Normal (n = 5)

71.02 (8.62-351.79)

0.3225

0.97 (0.12-1.66)

0.7163

Mild (n = 1)

405.48

0.4

 Crypt dilation and distorsion

6

Normal (n = 5)

249.74 (8.62-405.48)

0.5229

0.98 (0.37-1.66)

0.0715

Mild (n = 1)

34.02

0.12

 Mucosal fibrosis and atrophy

6

Normal (n = 6)

160.38 (8.62-405.48)

–

0.68 (0.12-1.66)

–

Inflammatory criteria

6

     

 Lamina propria LPC

6

Normal (n = 2)

211.41 (71.02-351.79)

0.6222

1.24 (0.97-1.51)

0.2594

Mild (n = 4)

141.88 (8.62-405.48)

0.38 (0.12-1.66)

 Lamina propria eosinophils

6

Normal (n = 3)

34.02 (8.62-249.74)

0.2181

0.37 (0.12-1.66)

0.4642

Mild (n = 3)

351.79 (71.02-405.48)

0.97 (0.4-1.51)

 Lamina propria neutrophils

6

Normal (n = 5)

71.02 (8.62-405.48)

0.4075

0.68 (0.12-1.66)

0.3664

Moderate (n = 1)

351.79

1.51

 Lamina propria macrophage

6

Normal (n = 6)

160.38 (8.62-405.48)

–

0.68 (0.12-1.66)

–

  1. Association between mucosal S100A12 concentrations and MPO activities with severity of histopathological findings in the colon and cecum of dogs with CE. Statistical differences were calculated based on the log-transformed values of S100A12 and MPO. Untransformed values are reported as median (IQR)
  2. n sample size, IQR interquartile range, LPC lymphocytes/plasma cells
  3. aANOVA test after logarithmic transformation of original values
  4. bstatistically significant association
Back to article page

BMC Veterinary Research

ISSN: 1746-6148

Contact us