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Table 2 Mucosal S100A12 and MPO levels in relation to histopathologic changes in the colon and cecum

From: S100A12 concentrations and myeloperoxidase activities are increased in the intestinal mucosa of dogs with chronic enteropathies

Histopathological findings n Severity groups S100A12 (μg/L)
Median (IQR)
P valuea MPO (ΔA/min)
Median (IQR)
P valuea
Colon 15      
 Total histopathological severity 15 Insignificant (n = 7) 49.01 (10.8-184.68) 0.0274 b 1.04 (0.22-3.37) 0.1280
Mild (n = 7) 111.4 (32.81-538.8) 1.49 (0.38-4.08)
Moderate (n = 1) 1296.65 6.61
Morphological criteria 15      
 Epithelial injury 15 Normal (n = 8) 44.18 (10.8-184.68) 0.0083 b 1.28 (0.22-4.08) 0.4232
Mild (n = 3) 254.57 (89.16-536.8) 1.49 (0.57-2.59)
Moderate (n = 3) 111.4 (32.81-211.53) 0.68 (0.38-3.01)
Severe (n = 1) 1296.65 6.61
 Crypt hyperplasia 15 Normal (n = 11) 89.61 (10.8-536.8) 0.8412 1.1 (0.22-3.37) 0.3437
Mild (n = 3) 33.53 (32.81-1296.65) 1.46 (0.68-6.61)
Moderate (n = 1) 44.9 4.08
 Crypt dilation and distorsion 15 Normal (n = 12) 76.01 (10.8-536.8) 0.5706 1.48 (0.22-4.08) 0.5858
Mild (n = 3) 49.01 (32.81-1296.65) 1.1 (0.68-6.61)
 Mucosal fibrosis and atrophy 15 Normal (n = 8) 53.97 (10.8-1296.65) 0.4267 0.86 (0.22-6.61) 0.9124
Mild (n = 5) 111.4 (43.45-254.57) 2.59 (0.38-3.37)
Moderate (n = 1) 536.8 1.49
Severe (n = 1) 33.53 1.46
Inflammatory criteria 15      
 Lamina propria LPC 15 Normal (n = 2) 312.98 (89.16-536.8) 0.0554 1.03 (0.57-1.49) 0.4088
Mild (n = 9) 49.01 (22.89-211.53) 1.1 (0.22-3.37)
Moderate (n = 3) 44.9 (10.8-254.57) 2.59 (0.28-4.08)
Severe (n = 1) 1296.65 6.61
 Lamina propria eosinophils 15 Normal (n = 9) 63.04 (10.8-254.57) 0.1076 1.04 (0.22-3.37) 0.1516
Mild (n = 3) 33.53 (22.89-89.16) 1.46 (0.57-2.04)
Moderate (n = 3) 536.8 (44.9-1296.65) 4.08 (1.49-6.61)
 Lamina propria neutrophils 15 Normal (n = 10) 46.96 (10.8-1296.65) 0.2448 1.07 (0.22-6.61) 0.9400
Mild (n = 4) 161.47 (33.53-254.57) 2.02 (0.38-3.01)
Moderate (n = 1) 536.8 1.49
 Lamina propria macrophage 15 Normal (n = 15) 63.04 (10.8-1296.65) 1.46 (0.22-6.61)
Cecum 6      
 Total histopathological severity 6 Insignificant (n = 6) 160.38 (8.62-405.48) 0.68 (0.12-1.66)
Morphological criteria 6      
 Epithelial injury 6 Normal (n = 3) 34.02 (8.62-249.74) 0.2187 0.37 (0.12-1.66) 0.4642
Mild (n = 3) 351.79 (71.02-405.48) 0.97 (0.4-1.51)
 Crypt hypeplasia 6 Normal (n = 5) 71.02 (8.62-351.79) 0.3225 0.97 (0.12-1.66) 0.7163
Mild (n = 1) 405.48 0.4
 Crypt dilation and distorsion 6 Normal (n = 5) 249.74 (8.62-405.48) 0.5229 0.98 (0.37-1.66) 0.0715
Mild (n = 1) 34.02 0.12
 Mucosal fibrosis and atrophy 6 Normal (n = 6) 160.38 (8.62-405.48) 0.68 (0.12-1.66)
Inflammatory criteria 6      
 Lamina propria LPC 6 Normal (n = 2) 211.41 (71.02-351.79) 0.6222 1.24 (0.97-1.51) 0.2594
Mild (n = 4) 141.88 (8.62-405.48) 0.38 (0.12-1.66)
 Lamina propria eosinophils 6 Normal (n = 3) 34.02 (8.62-249.74) 0.2181 0.37 (0.12-1.66) 0.4642
Mild (n = 3) 351.79 (71.02-405.48) 0.97 (0.4-1.51)
 Lamina propria neutrophils 6 Normal (n = 5) 71.02 (8.62-405.48) 0.4075 0.68 (0.12-1.66) 0.3664
Moderate (n = 1) 351.79 1.51
 Lamina propria macrophage 6 Normal (n = 6) 160.38 (8.62-405.48) 0.68 (0.12-1.66)
  1. Association between mucosal S100A12 concentrations and MPO activities with severity of histopathological findings in the colon and cecum of dogs with CE. Statistical differences were calculated based on the log-transformed values of S100A12 and MPO. Untransformed values are reported as median (IQR)
  2. n sample size, IQR interquartile range, LPC lymphocytes/plasma cells
  3. aANOVA test after logarithmic transformation of original values
  4. bstatistically significant association