Table 1 Organ dysfunction criteria adapted for use in the present study

Cardiovascular

Systolic blood pressure < 90 mmHg despite adequate fluid resuscitation

[51]

Hemostatic

PT > 7.5 s OR

aPTT > 16.5 s OR

Platelet count < 160 × 10⁹/L (< 160 × 10³/μL)

[3, 46]

Hepatic

Increase in serum bilirubin > 6.0 μmoL/L (> 0.35 mg/dL)

(in the absence of hemolysis or biliary obstruction)

[3, 46]

Renal

Serum creatinine (sCr) > 119.3 μmoL/L (> 1.35 mg/dL) OR

Increase in sCr of > 26.5 μmoL/L (≥ 0.3 mg/dL) from baseline OR

Oliguria (urine output < 1 mL/kg/h over 6 h)

[52]

Respiratory

SpO₂ < 95% on room air OR

SpO₂ / FiO₂ < 315 on supplemental oxygen OR

PaO₂ / FiO₂ < 400 mmHg on supplemental oxygen

[3, 46, 53]