Table 2 Summary data (mean ± SD) of bone structure and remodeling parameters from Day 0, Day 60 and Day 60R biopsies for micro-computed tomography (MicroCT), static and dynamic histomorphometry (histo) analyses. Groups are separated based on treatment received

Saline

Day 0 (n = 9)

Day 60 (n = 9)

Day 60R (n = 4)

Day 0 (n = 9)

Day 60 (n = 9)

Day 60R (n = 9)

Day 60 (n = 9)

BV/TV (%)

29.4 ± 5.0

32.0 ± 6.4

35.7 ± 17.1

BV/TV (%)

29.6 ± 10.9

24.7 ± 10.6

33.0 ± 15.7

sLS/BS (%)

26.2 ± 5.4

TbTh (mm)

0.16 ± 0.02

0.17 ± 0.02

0.20 ± 0.07

ES/BS (%)

1.96 ± 2.55^a

0.19 ± 0.17^b

0.12 ± 0.05^a

dLS/BS (%)

4.21 ± 2.17

TbN (/mm)

1.73 ± 0.22

1.72 ± 0.28

1.9 ± 0.4

NOb/TA (/mm²)

75.9 ± 58.1

63.6 ± 27.0^c

72.5 ± 22.1

MAR (μm/d)

1.16 ± 0.23

ConnD (/mm³)

7.84 ± 1.88

7.90 ± 2.79

9.1 ± 3.4

NOc/TA (/mm²)

0.45 ± 0.38

0.01 ± 0.02

1.00 ± 0.75

BFR/TV (%/yr)

26.2 ± 7.4

Tiludronate

Day 0 (n = 5)

Day 60 (n = 5)

Day 0 (n = 5)

Day 60 (n = 5)

Day 60 (n = 5)

BV/TV (%)

28.1 ± 3.9

31.1 ± 5.0

BV/TV (%)

24.1 ± 7.2

30.8 ± 6.8

sLS/BS (%)

24.4 ± 7.0

TbTh (mm)

0.16 ± 0.01

0.16 ± 0.02

ES/BS (%)

2.86 ± 1.38

1.49 ± 0.65^b

dLS/BS (%)

6.33 ± 4.59

TbN (/mm)

1.65 ± 0.17

1.81 ± 0.24

NOb/TA (/mm²)

29.7 ± 17.6

17.8 ± 11.3^c

MAR (μm/d)

1.16 ± 0.21

ConnD (/mm³)

7.46 ± 1.28

9.39 ± 3.17

NOc/TA (/mm²)

0.61 ± 0.41

0.06 ± 0.11

BFR/TV (%/yr)

29.8 ± 12.6

Clodronate

Day 0 (n= 3)

Day 60 (n = 5)

Day 60R (n = 5)

Day 0 (n = 5)

Day 60 (n = 5)

Day 60R (n = 5)

Day 60 (n = 5)

BV/TV (%)

32.3 ± 3.6

31.7 ± 2.9

39.2 ± 10.6

BV/TV (%)

30.7 ± 3.9

23.4 ± 4.8

34.5 ± 9.4

sLS/BS (%)

28.4 ± 19.0

TbTh (mm)

0.15 ± 0.02

0.16 ± 0.01

0.20 ± 0.04

ES/BS (%)

0.02 ± 0.03^d

0.14 ± 0.13

0.13 ± 0.06^d

dLS/BS (%)

4.3 ± 4.6

TbN (/mm)

1.95 ± 0.11

1.87 ± 0.18

2.22 ± 0.25

NOb/TA (/mm²)

88.3 ± 32.5

49.6 ± 16.0

63.4 ± 17.6

MAR (μm/d)

1.02 ± 0.29

ConnD (/mm³)

9.75 ± 1.02

8.85 ± 1.80

13.50 ± 2.96

NOc/TA (/mm²)

0.44 ± 0.61

0.04 ± 0.05

0.84 ± 0.40

BFR/TV (%/yr)

25.5 ± 15.2