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Table 3 In vitro activity of six antimicrobials against the Clostridium difficile dog isolates

From: Preliminary studies on isolates of Clostridium difficile from dogs and exotic pets

Antimicrobial agent Range (μg/ml) Breakpointa (μg/ml) Number resistant isolates (%)
Clindamycin 0′016–256 ≥8b 3/6 (50)
Erythromycin 0′016–256 ≥8 2/6 (33.3)
Metronidazole 0′016–256 ≥32b 2/6 (33.3)
Moxifloxacin 0′02–32 ≥8b 1/6 (16.7)
Tetracycline 0′016–256 ≥8 0
Vancomycin 0′016–256 ≥32 0
  1. aThe breakpoints for resistance established by the Clinical and Laboratory Standards Institute (CLSI) for anaerobic bacteria are those marked by b [50]. The breakpoint for tetracycline was ≥8 μg/ml [51]. The remaining breakpoints were based on the literature [7]