Preliminary studies on isolates of Clostridium difficile from dogs and exotic pets

BMC Veterinary Research

Table 3 In vitro activity of six antimicrobials against the Clostridium difficile dog isolates

Antimicrobial agent	Range (μg/ml)	Breakpoint^a (μg/ml)	Number resistant isolates (%)
Clindamycin	0′016–256	≥8^b	3/6 (50)
Erythromycin	0′016–256	≥8	2/6 (33.3)
Metronidazole	0′016–256	≥32^b	2/6 (33.3)
Moxifloxacin	0′02–32	≥8^b	1/6 (16.7)
Tetracycline	0′016–256	≥8	0
Vancomycin	0′016–256	≥32	0

^aThe breakpoints for resistance established by the Clinical and Laboratory Standards Institute (CLSI) for anaerobic bacteria are those marked by ^b [50]. The breakpoint for tetracycline was ≥8 μg/ml [51]. The remaining breakpoints were based on the literature [7]

ISSN: 1746-6148