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Table 4 Mean ± SD of Ins concentrations (mmol/L of brain water) and Ins/tCr ratios

From: Effects of isoflurane, sevoflurane, propofol and alfaxalone on brain metabolism in dogs assessed by proton magnetic resonance spectroscopy (1H MRS)

 

Dose 1

Dose 2

Dose 3

Arithmetic mean

Mean ± SD

Mean ± SD

Mean ± SD

Mean ± SD

Ins

BG

Isoflurane

7.931 ± 0.343

7.983 ± 0.589

7.730 ± 0.824

7.876 ± 0.529

Sevoflurane

8.365 ± 0.816

8.470 ± 0.780

8.344 ± 0.710

8.393 ± 0.701

Propofol

8.033 ± 0.561

8.056 ± 0.778

8.109 ± 0.646

8.100 ± 0.601

Alfaxalone

8.325 ± 0.606

8.446 ± 0.689

8.605 ± 0.487

8.459 ± 0.470

PL

Isoflurane

7.679 ± 0.996

8.176 ± 0.861

8.070 ± 0.716

8.016 ± 0.835

Sevoflurane

8.165 ± 0.445

8.367 ± 0.528

8.131 ± 0.485

8.221 ± 0.414

Propofol

8.178 ± 1.075

7.976 ± 1.266

7.833 ± 1.439

7.992 ± 1.196

Alfaxalone

7.967 ± 1.103

8.177 ± 1.078

8.188 ± 0.888

8.111 ± 0.954

OL

Isoflurane

8.005 ± 0.885

8.233 ± 0.871

8.077 ± 1.171

8.016 ± 1.087

Sevoflurane

8.362 ± 0.620

8.588 ± 0.554

8.342 ± 0.677

8.431 ± 0.579

Propofol

8.382 ± 0.611

8.455 ± 0.749

8.336 ± 0.593

8.501 ± 0.752

Alfaxalone

8.524 ± 0.649

8.449 ± 0.629

8.523 ± 0.572

8.499 ± 0.591

Ins/tCr

BG

Isoflurane

1.365 ± 0.114

1.299 ± 0.082

1.331 ± 0.100

1.326 ± 0.075

Sevoflurane

1.389 ± 0.132

1.333 ± 0.137

1.336 ± 0.095

1.353 ± 0.103

Propofol

1.351 ± 0.124

1.335 ± 0.112

1.353 ± 0.114

1.307 ± 0.167

Alfaxalone

1.319 ± 0.108

1.334 ± 0.099

1.340 ± 0.110

1.331 ± 0.081

PL

Isoflurane

1.417 ± 0.173

1.462 ± 0.145

1.439 ± 0.112

1.443 ± 0.136

Sevoflurane

1.510 ± 0.135

1.502 ± 0.084

1.457 ± 0.121

1.490 ± 0.107

Propofol

1.459 ± 0.221

1.451 ± 0.266

1.431 ± 0.271

1.440 ± 0.242

Alfaxalone

1.462 ± 0.214

1.509 ± 0.215

1.525 ± 0.211

1.498 ± 0.200

OL

Isoflurane

1.203 ± 0.081

1.205 ± 0.092

1.245 ± 0.113

1.220 ± 0.103

Sevoflurane

1.242 ± 0.090

1.258 ± 0.077

1.228 ± 0.115

1.243 ± 0.089

Propofol

1.235 ± 0.056

1.287 ± 0.197

1.120 ± 0.326

1.256 ± 0.232

Alfaxalone

1.262 ± 0.098

1.259 ± 0.100

1.304 ± 0.160

1.275 ± 0.113

  1. Mean ± SD for the three different doses and the arithmetic mean of the three doses for isoflurane, sevoflurane, propofol and alfaxalone in basal ganglia (BG), parietal lobe (PL) and occipital lobe (OL).