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Table 3 Mean ± SD of tCh concentrations (mmol L-1 of brain water) and tCh/tCr ratios

From: Effects of isoflurane, sevoflurane, propofol and alfaxalone on brain metabolism in dogs assessed by proton magnetic resonance spectroscopy (1H MRS)

 

Dose 1

Dose 2

Dose 3

Arithmetic mean

Mean ± SD

Mean ± SD

Mean ± SD

Mean ± SD

tCh

BG

Isoflurane

1.887 ± 0.112A

2.079 ± 0.110

1.932 ± 0.166A

1.969 ± 0.0891

Sevoflurane

1.971 ± 0.109A

2.107 ± 0.145B

2.068 ± 0.128AB

2.049 ± 0.10312

Propofol

2.034 ± 0.118

2.015 ± 0.109

2.010 ± 0.139

2.026 ± 0.09012

Alfaxalone

2.069 ± 0.103

2.082 ± 0.105

2.108 ± 0.123

2.086 ± 0.0802

PL

Isoflurane

1.805 ± 0.180A

1.885 ± 0.129B

1.841 ± 0.132AB

1.843 ± 0.134

Sevoflurane

1.721 ± 0.107A

1.806 ± 0.100B

1.747 ± 0.133AB

1.758 ± 0.101

Propofol

1.843 ± 0.117

1.773 ± 0.233

1.788 ± 0.204

1.768 ± 0.218

Alfaxalone

1.854 ± 0.103

1.822 ± 0.107

1.814 ± 0.162

1.830 ± 0.112

OL

Isoflurane

1.616 ± 0.288

1.805 ± 0.121

1.667 ± 0.202

1.653 ± 0.2581

Sevoflurane

1.707 ± 0.148A

1.807 ± 0.094B

1.768 ± 0.132AB

1.761 ± 0.11812

Propofol

1.795 ± 0.122

1.831 ± 0.122

1.832 ± 0.116

1.823 ± 0.1052

Alfaxalone

1.812 ± 0.140

1.802 ± 0.102

1.789 ± 0.092

1.801 ± 0.09712

tCh/tCr

BG

Isoflurane

0.324 ± 0.021

0.339 ± 0.017

0.331 ± 0.043

0.330 ± 0.027

Sevoflurane

0.329 ± 0.033

0.332 ± 0.031

0.331 ± 0.020

0.330 ± 0.025

Propofol

0.342 ± 0.017

0.335 ± 0.025

0.335 ± 0.024

0.337 ± 0.020

Alfaxalone

0.328 ± 0.020

0.331 ± 0.018

0.328 ± 0.017

0.329 ± 0.016

PL

Isoflurane

0.334 ± 0.039

0.338 ± 0.030

0.329 ± 0.029

0.332 ± 0.030

Sevoflurane

0.318 ± 0.033

0.324 ± 0.021

0.313 ± 0.023

0.319 ± 0.022

Propofol

0.329 ± 0.031

0.322 ± 0.047

0.325 ± 0.028

0.318 ± 0.043

Alfaxalone

0.342 ± 0.032

0.337 ± 0.027

0.338 ± 0.040

0.339 ± 0.030

OL

Isoflurane

0.242 ± 0.031A

0.265 ± 0.010B

0.257 ± 0.008AB

0.251 ± 0.026

Sevoflurane

0.253 ± 0.020

0.265 ± 0.015

0.260 ± 0.023

0.260 ± 0.018

Propofol

0.265 ± 0.014

0.278 ± 0.028

0.268 ± 0.023

0.275 ± 0.027

Alfaxalone

0.268 ± 0.018

0.268 ± 0.016

0.273 ± 0.019

0.270 ± 0.015

  1. Mean ± SD for the three different doses and the arithmetic mean of the three doses for isoflurane, sevoflurane, propofol and alfaxalone in basal ganglia (BG), parietal lobe (PL) and occipital lobe (OL). Different alphabetical superscripts differ significantly (p < 0.05) between different doses of each anesthetic different numerical superscripts differ significantly between arithmetic mean tCh concentrations of each anesthetic