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Table 2 Mean ± SD of tNAA concentrations (mmol L-1 of brain water) and tNAA/tCr ratios

From: Effects of isoflurane, sevoflurane, propofol and alfaxalone on brain metabolism in dogs assessed by proton magnetic resonance spectroscopy (1H MRS)

  Dose 1 Dose 2 Dose 3 Arithmetic mean
Mean ± SD Mean ± SD Mean ± SD Mean ± SD
tNAA BG Isoflurane 6.911 ± 0.753 7.318 ± 0.425 6.955 ± 0.387 7.094 ± 0.339
Sevoflurane 7.100 ± 0.548 7.297 ± 0.554 7.219 ± 0.512 7.205 ± 0.509
Propofol 7.288 ± 0.484AB 7.007 ± 0.466A 7.524 ± 0.618B 7.226 ± 0.444
Alfaxalone 7.104 ± 0.472A 7.499 ± 0.410AB 7.724 ± 0.541B 7.442 ± 0.376
PL Isoflurane 7.485 ± 0.585 7.692 ± 0.379 7.575 ± 0.360 7.583 ± 0.321
Sevoflurane 7.664 ± 0.490 7.631 ± 0.690 7.673 ± 0.526 7.656 ± 0.540
Propofol 7.622 ± 0.538 7.592 ± 0.617 7.667 ± 0.528 7.595 ± 0.516
Alfaxalone 7.681 ± 0.364 7.704 ± 0.376 7.805 ± 0.449 7.730 ± 0.282
OL Isoflurane 7.725 ± 0.309 7.898 ± 0.497 7.599 ± 0.934 7.696 ± 0.556
Sevoflurane 7.788 ± 0.642 7.907 ± 0.496 7.837 ± 0.492 7.844 ± 0.494
Propofol 7.859 ± 0.393 7.741 ± 0.490 7.628 ± 0.398 7.687 ± 0.432
Alfaxalone 7.680 ± 0.472 7.675 ± 0.559 7.426 ± 0.724 7.594 ± 0.498
tNAA/tCr BG Isoflurane 1.187 ± 0.126 1.195 ± 0.095 1.212 ± 0.108 1.203 ± 0.095
Sevoflurane 1.183 ± 0.125 1.148 ± 0.108 1.157 ± 0.086 1.163 ± 0.099
Propofol 1.229 ± 0.100 1.166 ± 0.117 1.255 ± 0.102 1.205 ± 0.107
Alfaxalone 1.126 ± 0.098 1.272 ± 0.238 1.202 ± 0.105 1.200 ± 0.110
PL Isoflurane 1.381 ± 0.100 1.377 ± 0.103 1.349 ± 0.071 1.365 ± 0.065
Sevoflurane 1.416 ± 0.134 1.369 ± 0.108 1.381 ± 0.083 1.389 ± 0.095
Propofol 1.361 ± 0.151 1.382 ± 0.172 1.404 ± 0.174 1.370 ± 0.159
Alfaxalone 1.419 ± 0.135 1.429 ± 0.134 1.450 ± 0.130 1.433 ± 0.119
OL Isoflurane 1.167 ± 0.078 1.158 ± 0.047 1.170 ± 0.053 1.175 ± 0.066
Sevoflurane 1.157 ± 0.093 1.158 ± 0.052 1.153 ± 0.069 1.156 ± 0.063
Propofol 1.160 ± 0.054AB 1.171 ± 0.060A 1.113 ± 0.052B 1.156 ± 0.054
Alfaxalone 1.137 ± 0.076 1.144 ± 0.089 1.127 ± 0.064 1.136 ± 0.064
  1. Mean ± SD for the three different doses and the arithmetic mean of the three doses for isoflurane, sevoflurane, propofol and alfaxalone in basal ganglia (BG), parietal lobe (PL) and occipital lobe (OL). Different alphabetical superscripts differ significantly (p < 0.05) between different doses of each anesthetic