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Table 2 Mean ± SD of tNAA concentrations (mmol L-1 of brain water) and tNAA/tCr ratios

From: Effects of isoflurane, sevoflurane, propofol and alfaxalone on brain metabolism in dogs assessed by proton magnetic resonance spectroscopy (1H MRS)

 

Dose 1

Dose 2

Dose 3

Arithmetic mean

Mean ± SD

Mean ± SD

Mean ± SD

Mean ± SD

tNAA

BG

Isoflurane

6.911 ± 0.753

7.318 ± 0.425

6.955 ± 0.387

7.094 ± 0.339

Sevoflurane

7.100 ± 0.548

7.297 ± 0.554

7.219 ± 0.512

7.205 ± 0.509

Propofol

7.288 ± 0.484AB

7.007 ± 0.466A

7.524 ± 0.618B

7.226 ± 0.444

Alfaxalone

7.104 ± 0.472A

7.499 ± 0.410AB

7.724 ± 0.541B

7.442 ± 0.376

PL

Isoflurane

7.485 ± 0.585

7.692 ± 0.379

7.575 ± 0.360

7.583 ± 0.321

Sevoflurane

7.664 ± 0.490

7.631 ± 0.690

7.673 ± 0.526

7.656 ± 0.540

Propofol

7.622 ± 0.538

7.592 ± 0.617

7.667 ± 0.528

7.595 ± 0.516

Alfaxalone

7.681 ± 0.364

7.704 ± 0.376

7.805 ± 0.449

7.730 ± 0.282

OL

Isoflurane

7.725 ± 0.309

7.898 ± 0.497

7.599 ± 0.934

7.696 ± 0.556

Sevoflurane

7.788 ± 0.642

7.907 ± 0.496

7.837 ± 0.492

7.844 ± 0.494

Propofol

7.859 ± 0.393

7.741 ± 0.490

7.628 ± 0.398

7.687 ± 0.432

Alfaxalone

7.680 ± 0.472

7.675 ± 0.559

7.426 ± 0.724

7.594 ± 0.498

tNAA/tCr

BG

Isoflurane

1.187 ± 0.126

1.195 ± 0.095

1.212 ± 0.108

1.203 ± 0.095

Sevoflurane

1.183 ± 0.125

1.148 ± 0.108

1.157 ± 0.086

1.163 ± 0.099

Propofol

1.229 ± 0.100

1.166 ± 0.117

1.255 ± 0.102

1.205 ± 0.107

Alfaxalone

1.126 ± 0.098

1.272 ± 0.238

1.202 ± 0.105

1.200 ± 0.110

PL

Isoflurane

1.381 ± 0.100

1.377 ± 0.103

1.349 ± 0.071

1.365 ± 0.065

Sevoflurane

1.416 ± 0.134

1.369 ± 0.108

1.381 ± 0.083

1.389 ± 0.095

Propofol

1.361 ± 0.151

1.382 ± 0.172

1.404 ± 0.174

1.370 ± 0.159

Alfaxalone

1.419 ± 0.135

1.429 ± 0.134

1.450 ± 0.130

1.433 ± 0.119

OL

Isoflurane

1.167 ± 0.078

1.158 ± 0.047

1.170 ± 0.053

1.175 ± 0.066

Sevoflurane

1.157 ± 0.093

1.158 ± 0.052

1.153 ± 0.069

1.156 ± 0.063

Propofol

1.160 ± 0.054AB

1.171 ± 0.060A

1.113 ± 0.052B

1.156 ± 0.054

Alfaxalone

1.137 ± 0.076

1.144 ± 0.089

1.127 ± 0.064

1.136 ± 0.064

  1. Mean ± SD for the three different doses and the arithmetic mean of the three doses for isoflurane, sevoflurane, propofol and alfaxalone in basal ganglia (BG), parietal lobe (PL) and occipital lobe (OL). Different alphabetical superscripts differ significantly (p < 0.05) between different doses of each anesthetic