| |
Dose 1
|
Dose 2
|
Dose 3
|
Arithmetic mean
|
|---|
|
Mean ± SD
|
Mean ± SD
|
Mean ± SD
|
Mean ± SD
|
|---|
|
tNAA
|
BG
|
Isoflurane
|
6.911 ± 0.753
|
7.318 ± 0.425
|
6.955 ± 0.387
|
7.094 ± 0.339
|
|
Sevoflurane
|
7.100 ± 0.548
|
7.297 ± 0.554
|
7.219 ± 0.512
|
7.205 ± 0.509
|
|
Propofol
|
7.288 ± 0.484AB
|
7.007 ± 0.466A
|
7.524 ± 0.618B
|
7.226 ± 0.444
|
|
Alfaxalone
|
7.104 ± 0.472A
|
7.499 ± 0.410AB
|
7.724 ± 0.541B
|
7.442 ± 0.376
|
|
PL
|
Isoflurane
|
7.485 ± 0.585
|
7.692 ± 0.379
|
7.575 ± 0.360
|
7.583 ± 0.321
|
|
Sevoflurane
|
7.664 ± 0.490
|
7.631 ± 0.690
|
7.673 ± 0.526
|
7.656 ± 0.540
|
|
Propofol
|
7.622 ± 0.538
|
7.592 ± 0.617
|
7.667 ± 0.528
|
7.595 ± 0.516
|
|
Alfaxalone
|
7.681 ± 0.364
|
7.704 ± 0.376
|
7.805 ± 0.449
|
7.730 ± 0.282
|
|
OL
|
Isoflurane
|
7.725 ± 0.309
|
7.898 ± 0.497
|
7.599 ± 0.934
|
7.696 ± 0.556
|
|
Sevoflurane
|
7.788 ± 0.642
|
7.907 ± 0.496
|
7.837 ± 0.492
|
7.844 ± 0.494
|
|
Propofol
|
7.859 ± 0.393
|
7.741 ± 0.490
|
7.628 ± 0.398
|
7.687 ± 0.432
|
|
Alfaxalone
|
7.680 ± 0.472
|
7.675 ± 0.559
|
7.426 ± 0.724
|
7.594 ± 0.498
|
|
tNAA/tCr
|
BG
|
Isoflurane
|
1.187 ± 0.126
|
1.195 ± 0.095
|
1.212 ± 0.108
|
1.203 ± 0.095
|
|
Sevoflurane
|
1.183 ± 0.125
|
1.148 ± 0.108
|
1.157 ± 0.086
|
1.163 ± 0.099
|
|
Propofol
|
1.229 ± 0.100
|
1.166 ± 0.117
|
1.255 ± 0.102
|
1.205 ± 0.107
|
|
Alfaxalone
|
1.126 ± 0.098
|
1.272 ± 0.238
|
1.202 ± 0.105
|
1.200 ± 0.110
|
|
PL
|
Isoflurane
|
1.381 ± 0.100
|
1.377 ± 0.103
|
1.349 ± 0.071
|
1.365 ± 0.065
|
|
Sevoflurane
|
1.416 ± 0.134
|
1.369 ± 0.108
|
1.381 ± 0.083
|
1.389 ± 0.095
|
|
Propofol
|
1.361 ± 0.151
|
1.382 ± 0.172
|
1.404 ± 0.174
|
1.370 ± 0.159
|
|
Alfaxalone
|
1.419 ± 0.135
|
1.429 ± 0.134
|
1.450 ± 0.130
|
1.433 ± 0.119
|
|
OL
|
Isoflurane
|
1.167 ± 0.078
|
1.158 ± 0.047
|
1.170 ± 0.053
|
1.175 ± 0.066
|
|
Sevoflurane
|
1.157 ± 0.093
|
1.158 ± 0.052
|
1.153 ± 0.069
|
1.156 ± 0.063
|
|
Propofol
|
1.160 ± 0.054AB
|
1.171 ± 0.060A
|
1.113 ± 0.052B
|
1.156 ± 0.054
|
|
Alfaxalone
|
1.137 ± 0.076
|
1.144 ± 0.089
|
1.127 ± 0.064
|
1.136 ± 0.064
|
- Mean ± SD for the three different doses and the arithmetic mean of the three doses for isoflurane, sevoflurane, propofol and alfaxalone in basal ganglia (BG), parietal lobe (PL) and occipital lobe (OL). Different alphabetical superscripts differ significantly (p < 0.05) between different doses of each anesthetic
