Characters | F/98 | nF47 | nF52 | vF47 |
---|---|---|---|---|
HI titer | 512 | 256 | 16 | 16 |
Change in HI titer compare to F/98 | Â | 2-fold | 32-fold | 32-fold |
EMDT (h)a | 86 | 79 | 68.5 | 75 |
Change in EMDT(h)compare to F/98 | Â | 7 | 17.5 | 11 |
EID50 (log10 EID50/0.2Â ml) | 6.67 | 7.64 | 8.74 | 7.77 |
Changed in EID50 compare to F/98 (log10 decrease) | Â | 9.3-fold** | 117.5-fold**## | 12.5 fold** |
Mutationsb compare to F/98 (start-end passage of mutant) | Â | PB2: S155Â N, C228Y, K375R (nF46-nF80) | PB2:S155Â N, C228Y, K375R (nF46-nF80) | PB2: I185K, C228Y, K375R (vF43-vF80) |
 |  | PB1: none | PB1:T156A, R189K (nF49-nF80) | PB1: none |
 |  | PA: none | PA: none | PA: none |
 |  | HA: K131R (nF30) | HA: K131R(nF30-nF80), S145 N, G181E, A198V (nF52-nF80) | HA: K131R, S145 N, G181E, A198V (vF47-vF80) |
 |  | NP: none | NP: R99K (nF50-nF80) | NP: none |
 |  | NA: none | NA: A459T (nF52-nF80) | NA: none |
 |  | M: none | M: none | M: none |
 |  | NS1: none | NS1: A143T (nF50-nF80) | NS1: none |