From: Systematic review of antiepileptic drugs’ safety and effectiveness in feline epilepsy
Study design | Risk of bias | Disease definitions (characterization) | Study groups size | ||||||
---|---|---|---|---|---|---|---|---|---|
Blinding of outcome assessment | Randomization | allocation concealment | Incomplete outcome data | Selective reporting | other sources of bias | ||||
Engel et al. [20]study 1 | bRELAS | low | low | high | low | high | high; company funding | well | very small |
Engel et al. [20] study 2 | low | low | high | low | high | high; company funding | well | very small | |
Lowrie et al. [26] | nbRCT | high | low | high | high | low | unclear | poorly | good |
Sawchuk et al. [47] | nbRELAS | high | low | low | low | high | unclear | clear | small |
Carnes et al. [42] | high | low | high | low | high | unclear | clear | small | |
Engel et al. [20] study 3 | UCT | high | high | high | low | high | high; company funding | well | very small |
Dewey et al. [41] | high | high | high | low | high | high; conference abstract | unclear | very small | |
Ukai et al. [51] | high | high | high | high | high | unclear | well | very small | |
Volk et al. [36] | high | high | high | low | low | high; conference abstract | well | very small | |
Bailey et al. [40] | high | high | high | high | high | unclear | fairly | small | |
Roye et al. [48] | UELAS | high | high | high | low | high | unclear | unclear | very small |
Barnard et al. [43] | high | high | high | low | high | unclear; conference abstract | clear | very small | |
Solomon et al. [34] | high | high | high | low | high | unclear | unclear | very small | |
Hasegawa et al. [50] | high | high | high | low | high | unclear | unclear | very small | |
Pellegrini et al. [53] | high | high | high | low | high | unclear | unclear | very small | |
Cochrane, Black et al. [32] | high | high | high | low | high | unclear | clear | very small | |
Cochrane, Parent et al. [33] | high | high | high | low | high | unclear | clear | very small | |
Boothe et al. [21] | high | high | high | low | high | low | clear | very small | |
Cautela et al. [52] | high | high | high | low | high | high; conference abstract | clear | very small | |
Gasper et al. [35] | high | high | high | high | high | unclear | clear | small | |
Dreimann [55] | high | high | high | low | high | High; abstract; dissertation | unclear | small | |
Schwartz-Porsche and Kaiser [44] | retrospective case series | NA | unclear | moderate | |||||
Brewer et al. [49] | unclear | very small | |||||||
Center et al. [45] | unclear | small | |||||||
Hughes et al. [46] | clear | very small | |||||||
Wagner [38] | unclear | moderate | |||||||
Boothe et al. [21] | unclear | small | |||||||
Volk et al. [28] | well | small | |||||||
Schriefl et al. [4] | fairly | small | |||||||
Bertolani et al. [37] | unclear | very small | |||||||
Pakozdy et al. [27] | fairly | moderate | |||||||
Finnerty et al. [25] | well | small | |||||||
Wahle et al. [31] | well | small | |||||||
Ducote et al. [23] | Case reports | NA | NA | very small | |||||
Zoran et al. [54] | clear | very small | |||||||
Lieser and Schwedes 2016 | NA | very small | |||||||
Boydell [29] | well | very small | |||||||
Baho et al. [22] | NA | very small | |||||||
Klang et al. [39] | well | very small | |||||||
Cuff et al. [30] | well | very small |