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Table 1 ROTEM and standard coagulation profiles results, before and 24 h after hydroxyethyl starch 130/0.4 infusion

From: Thromboelastometric assessment of hemostasis following hydroxyethyl starch (130/0.4) administration as a constant rate infusion in hypoalbuminemic dogs

 

GROUP 1 (1 ml / kg / h) N = 11

GROUP 2 (2 ml / kg / h) N = 9

Institutional reference ranges

ROTEM

T0

T1

T0

T1

 

In-TEM®

 CT (s)

180 (132–268)

166 (61–209)

188 (112–279)

141 (108–240)

126–363 s

 CFT (s)

63 (45–132)

59 (41–113)

73 (41–86)

58 * (38–81)

47–224 s

 MCF (mm)

72 (56–80)

72 (58–88)

68 (62–77)

72 (62–78)

50–75 mm

 α angle (°)

77 (65–81)

79 (69–82)

76 (73–82)

78 * (74–82)

55–81 °

Ex-TEM®

 CT (s)

44 (27–61)

45 (20–77)

46 (30–89)

40 (33–80)

29–92 s

 CFT (s)

67 (38–159)

78 (49–132)

81 (51–96)

62 (49–92)

54–275 s

 MCF (mm)

77 (60–82)

70 (64–83)

70 (66–81)

72 * (67–86)

36–73 mm

 α angle (°)

76 (61–83)

76 (65–82)

74 (71–80)

77 * (73–81)

47–79 °

Fib-TEM®

 CT (s)

47 (31–107)

39 (21–57)

45 (29–92)

39 (32–80)

14–102 s

 MCF (mm)

25 (7–38)

16 (8–46)

15 (9–30)

20 (14–78)

6–26 mm

 α angle (°)

77,5 (70–86)

76 (30–86)

76,5 (67–81)

77 (71–84)

40–78 °

 MCEplatelet

294 (142–404)

211 (169–441)

206 (175–383)

235 (183–571)

50–235

Standard coagulation

 aPTT (s)

12.5 (9.6–15.4)

12.3 (8.7–16)

13.9 (12.1–16)

14.5 (11.7–16)

12–16 s

 PT (s)

7.5 (6.6–9.6)

7.15 (6.6–9.9)

7.4 (6.2–10)

7.3 (6.3–10)

8–10 s

 Fibrinogen (g/L)

3.5 (2.5–8.5)

3.6 (2.4–7.9)

3.4 (2.2–7.4)

4.1 (2.2–7.1)

1.5–4.50 (g/L)

  1. Values are expressed as median (minimum-maximum)
  2. Values of institutional reference ranges for ROTEM parameters are expressed as 95% confidence intervals14
  3. In-TEM® intrinsic thromboelastometry pathway, Ex-TEM® extrinsic thromboelastometry pathway, Fib-TEM® functional fibrinogen, CT clotting time, CFT clot formation time, MCF maximum clot firmness, PT prothrombin time, aPTT activated partial thromboplastin time
  4. * Indicates statistically significant differences between T0 and T1 (P < 0.05)