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Table 1 Estimated ratios along and coefficients with p-values of the fixed effects on factors associated with animal MAP-ELISA results from individual milk sample in 691 herds and 45,652 cows (tested ones) from four states in the north of USA

From: Identifying individual animal factors associated with Mycobacterium avium subsp. paratuberculosis (MAP) milk ELISA positivity in dairy cattle in the Midwest region of the United States

Variables N Positive (%) Univariable analysis Multivariable analysis
  p-value* odds ratio (CI95%) β S.E. odds ratio (CI95%) p-value*
Age (years)    < 0.001      < 0.001
1.25 to ≤4 26,152 3.5%
> 4 to ≤8 18,384 6.7% < 0.001 2.20 (1.99–2.43) 0.724 0.053 1.99 (1.81–2.19) < 0.001
> 8 to 15.29 1115 7.1% < 0.001 2.43 (1.86–3.17) 0.728 0.137 1.98 (1.55–2.54) < 0.001
Somatic cell count (×1000/ml)    < 0.001      < 0.001
1.0 to ≤ .4 11,711 3.2%
> 14 to ≤26 11,630 3.9% 0.05 1.15 (0.99–1.34) 0.058 0.078 1.05 (0.91–1.21) 0.45
> 26 to ≤39 10,622 5.3% < 0.001 1.65 (1.43–1.91) 0.272 0.078 1.36 (1.18–1.56) < 0.001
> 39 to 97 11,447 7.2% < 0.001 2.33 (2.03–2.68) 0.467 0.077 1.66 (1.44–1.90) < 0.001
Number of lactation    < 0.001      
0 to ≤1 14,072 3.3%     
> 1 to ≤2 15,521 4.4% < 0.001 1.68 (1.47–1.92)     
> 2 to ≤3 8681 6.0% < 0.001 2.36 (2.05–2.73)     
> 3 to 11 7378 7.4% < 0.001 2.99 (2.58–3.46)     
Milk production (pounds)    < 0.001      < 0.001
0 to ≤52 12,220 7.7%
> 52 to ≤68 11,384 4.4% < 0.001 0.53 (0.47–0.61) − 0.507 0.066 0.66 (0.59–0.75) < 0.001
> 68 to ≤86 11,465 3.7% < 0.001 0.44 (0.38–0.51) − 0.722 0.076 0.56 (0.49–0.65) < 0.001
> 86 to 192 10,524 3.3% < 0.001 0.35 (0.30–0.42) −1.110 0.093 0.43 (0.36–0.51) < 0.001
Milk fat (%)    0.03      
0 to ≤3.5 12,549 4.4%     
> 3.5 to ≤3.9 9903 4.5% 0.89 1.00 (0.88–1.15)     
> 3.9 to ≤4.5 12,657 4.7% 0.98 1.00 (0.87–1.13)     
> 4.5 to 9.9 10,543 5.9% 0.01 1.17 (1.03–1.34)     
Milk protein (%)    0.001      < 0.001
0 to ≤3.0 12,418 4.9%
> 3.0 to ≤3.3 13,952 4.1% 0.008 0.84 (0.73–0.95) −0.262 0.072 0.76 (0.67–0.87) < 0.001
> 3.3 to ≤3.5 8224 5.0% 0.61 0.96 (0.83–1.11) − 0.261 0.083 0.74 (0.64–0.85) 0.001
> 3.5 to 7.4 11,058 5.7% 0.28 1.07 (0.93–1.23) −0.380 0.083 0.67 (0.58–0.77) < 0.001
Milk urea nitrogen (mg/dl)    0.17      
0 to ≤5 12,076 4.7%     
> 5 to ≤11 14,833 5.0% 0.77 1.02 (0.87–1.19)     
> 11 to ≤13 8087 5.0% 0.52 1.05 (0.88–1.26)     
> 13 to 81 10,656 4.7% 0.26 0.90 (0.76–1.07)     
Previous-305-d mature equivalent (305ME)(Kg)    < 0.001      
0 to ≤21,120 11,687 6.6%     
> 21,120 to ≤25,690 11,540 5.1% < 0.001 0.69 (0.60–0.79)     
> 25,690 to ≤29,550 11,253 4.3% < 0.001 0.55 (0.47–0.64)     
> 29,550 to 46,720 11,171 3.3% < 0.001 0.42 (0.35–0.50)     
305-d mature equivalent (305ME)(Kg)    < 0.001      
0 to ≤20,220 11,718 6.8%     
> 20,220 to ≤25,370 11,485 5.1% < 0.001 0.65 (0.57–0.74)     
> 25,370 to ≤29,400 11,256 4.2% < 0.001 0.53 (0.46–0.62)     
> 29,400 to 46,720 11,192 3.2% < 0.001 0.39 (0.33–0.46)     
Lactation persistence (%)    < 0.001      
1 to ≤100 14,022 6.1%     
> 100 to ≤108 9976 5.0% < 0.001 0.79 (0.70–0.90)     
> 108 to ≤116 11,286 4.0% < 0.001 0.60 (0.52–0.69)     
> 116 to ≤225 10,368 4.0% < 0.001 0.58 (0.51–0.67)     
Days in milk    < 0.001      < 0.001
< 30 3658 6.4%
−31-60 3280 5.3% 0.39 0.90 (0.72–1.13) 0.007 0.120 1.00 (0.79–1.27) 0.94
61–90 1950 3.1% < 0.001 0.49 (0.35–0.68) −0.580 0.169 0.55 (0.40–0.78) < 0.001
91–120 1604 4.5% 0.01 0.67 (0.48–0.92) −0.283 0.167 0.75 (0.54–1.04) 0.08
121–150 1351 4.3% 0.01 0.63 (0.45–0.89) −0.403 0.180 0.66 (0.46–0.95) 0.02
151–180 1224 5.6% 0.07 0.74 (0.53–1.03) −0.243 0.173 0.78 (0.55–1.10) 0.16
181–210 1862 5.0% 0.22 0.83 (0.62–1.11) −0.152 0.154 0.85 (0.63–1.16) 0.32
211–240 3336 3.6% < 0.001 0.61 (0.46–0.80) −0.513 0.143 0.59 (0.45–0.79) < 0.001
241–270 6743 3.6% < 0.001 0.57 (0.45–0.73) −0.615 0.124 0.54 (0.42–0.69) < 0.001
271–300 6498 4.6% 0.001 0.68 (0.54–0.85) −0.558 0.124 0.57 (0.44–0.72) < 0.001
> 301 14,146 5.7% 0.12 0.85 (0.69–1.04) −0.557 0.116 0.57 (0.45–0.71) < 0.001
Season of cow’s birth    0.07      
Winter (Dec-Feb) 12,339 5.3%     
Spring (Mar-May) 11,100 5.0% 0.16 0.91 (0.80–1.03)     
Summer (Jun-Aug) 12,134 4.5% 0.01 0.84 (0.74–0.96)     
Fall (Sep-Nov) 10,079 4.7% 0.05 0.88 (0.77–1.00)     
  1. *p-values from the Likelihood-ratio test