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Table 4 Milk pharmacokinetic parameters (means ± SD) of danofloxacin after i.m. administration at a dosage of 1.25 mg/kg in the three experimental groups; n = 6

From: Flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep

Parameter Control Flaxseed 10% Flaxseed 15%
AUC 0–24 (μg·h/mL) 19.17 ± 5.03 14.58 ± 1.79a 13.43 ± 3.07a
AUC 0-∞ (μg·h/mL) 19.44 ± 5.12 14.86 ± 1.86a 13.68 ± 3.13a
Cmax (μg/mL) 2.95 ± 0.74 2.20 ± 0.35a 1.84 ± 0.44a
MRT (h) 5.35 ± 0.87 5.25 ± 0.35 5.54 ± 0.29
Tmax (h) 2.66 ± 0.94 3.00 ± 1.00 2.66 ± 0.94
AUC 0–24 milk/plasma 11.04 ± 1.95 7.81 ± 2.08a 7.57 ± 2.10a
  1. aSignificantly different from the control group (P < 0.05)